about
A systems approach to prion diseaseHighly efficient protein misfolding cyclic amplificationDe novo generation of infectious prions in vitro produces a new disease phenotypeUltra-efficient PrP(Sc) amplification highlights potentialities and pitfalls of PMCA technologyRe-assessment of PrP(Sc) distribution in sporadic and variant CJDIntraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep.Estimating prion concentration in fluids and tissues by quantitative PMCA.Protein misfolding cyclic amplification of infectious prions.Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassaysPathogenesis of chronic wasting disease in cervidized transgenic mice.Relationship between conformational stability and amplification efficiency of prions.A new perspective on Darwin's Pangenesis.Lack of prion transmission by sexual or parental routes in experimentally infected hamstersPopulation screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study.Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.Prions in the urine of patients with variant Creutzfeldt-Jakob disease.Highly efficient amplification of chronic wasting disease agent by protein misfolding cyclic amplification with beads (PMCAb).Patterning techniques for metal organic frameworks.Assessment of strain-specific PrP(Sc) elongation rates revealed a transformation of PrP(Sc) properties during protein misfolding cyclic amplificationFirst demonstration of transmissible spongiform encephalopathy-associated prion protein (PrPTSE) in extracellular vesicles from plasma of mice infected with mouse-adapted variant Creutzfeldt-Jakob disease by in vitro amplification.Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infectionMother to offspring transmission of chronic wasting disease in reeves' muntjac deer.Gold nanorods 3D-supercrystals as surface enhanced Raman scattering spectroscopy substrates for the rapid detection of scrambled prionsPrion disease blood test using immunoprecipitation and improved quaking-induced conversionRed-backed vole brain promotes highly efficient in vitro amplification of abnormal prion protein from macaque and human brains infected with variant Creutzfeldt-Jakob disease agent.In vitro detection of prionemia in TSE-infected cervids and hamsters.Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins.Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake.Recent advances in prion chemotherapeutics.In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrateReal time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob diseasePreclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion diseaseRecent developments in mucosal vaccines against prion diseases.Reduction of prion infectivity in packed red blood cells.Identification of misfolded proteins in body fluids for the diagnosis of prion diseases.Prions: Beyond a Single Protein.Getting to the core of prion superstructural variability.Prions efficiently cross the intestinal barrier after oral administration: Study of the bioavailability, and cellular and tissue distribution in vivo.Prions are secreted in milk from clinically normal scrapie-exposed sheep.De novo generation of infectious prions with bacterially expressed recombinant prion protein.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Presymptomatic detection of prions in blood.
@en
Presymptomatic detection of prions in blood.
@nl
type
label
Presymptomatic detection of prions in blood.
@en
Presymptomatic detection of prions in blood.
@nl
prefLabel
Presymptomatic detection of prions in blood.
@en
Presymptomatic detection of prions in blood.
@nl
P2860
P356
P1433
P1476
Presymptomatic detection of prions in blood
@en
P2093
Claudio Soto
P2860
P356
10.1126/SCIENCE.1129051
P407
P577
2006-07-01T00:00:00Z