Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.
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Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motilityA molecular link between the active component of marijuana and Alzheimer's disease pathologyAlzheimer's disease; taking the edge off with cannabinoids?Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseThe pharmacology and therapeutic potential of (-)-huperzine A.Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's diseaseHeterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides.Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1.Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer diseaseStructure-based search for new inhibitors of cholinesterases.Butyrylcholinesterase attenuates amyloid fibril formation in vitro.Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse modelNicotine attenuates beta-amyloid peptide-induced neurotoxicity, free radical and calcium accumulation in hippocampal neuronal cultures.2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution.Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors?Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on.Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus.Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss.Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's DiseaseAmyloid-beta alters trafficking of internalized acetylcholinesterase and dextran.Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation.Synthesis and application of β-carbolines as novel multi-functional anti-Alzheimer's disease agents.The neuroprotective role of melatonin in neurological disorders.
P2860
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P2860
Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@en
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@nl
type
label
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@en
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@nl
prefLabel
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@en
Stable complexes involving ace ...... xicity of Alzheimer's fibrils.
@nl
P2093
P1476
Stable complexes involving ace ...... oxicity of Alzheimer's fibrils
@en
P2093
B P Doctor
E O Campos
F G De Mello
F H Calderón
M K Gentry
N C Inestrosa
P304
P356
10.1523/JNEUROSCI.18-09-03213.1998
P407
P577
1998-05-01T00:00:00Z