Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase.
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Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTppPyruvate kinase: Function, regulation and role in cancerThe pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allosteryM2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinaseStructures of pyruvate kinases display evolutionarily divergent allosteric strategiesDistinguishing the Interactions in the Fructose 1,6-Bisphosphate Binding Site of Human Liver Pyruvate Kinase That Contribute to AllosteryMetabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN ratsIdentification of allosteric-activating drug leads for human liver pyruvate kinaseModulation of allostery of pyruvate kinase by shifting of an ensemble of microstates.Impairment of adult hippocampal neural progenitor proliferation by methamphetamine: role for nitrotyrosination.What Mutagenesis Can and Cannot Reveal About Allostery.Allostery: an illustrated definition for the 'second secret of life'.Benchmarking predictions of allostery in liver pyruvate kinase in CAGI4.Exploring the limits of the usefulness of mutagenesis in studies of allosteric mechanisms.Whole-protein alanine-scanning mutagenesis of allostery: A large percentage of a protein can contribute to mechanism.PKM2, cancer metabolism, and the road ahead.A look at ligand binding thermodynamics in drug discovery.Identification of regions of rabbit muscle pyruvate kinase important for allosteric regulation by phenylalanine, detected by H/D exchange mass spectrometry.Monitoring allostery in D2O: a necessary control in studies using hydrogen/deuterium exchange to characterize allosteric regulation.Allosteric regulation of human liver pyruvate kinase by peptides that mimic the phosphorylated/dephosphorylated N-terminus.The importance of polarity in the evolution of the K+ binding site of pyruvate kinase.Distinguishing the chemical moiety of phosphoenolpyruvate that contributes to allostery in muscle pyruvate kinase.Co-administration of creatine plus pyruvate prevents the effects of phenylalanine administration to female rats during pregnancy and lactation on enzymes activity of energy metabolism in cerebral cortex and hippocampus of the offspring.The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine.Changes in small-angle X-ray scattering parameters observed upon binding of ligand to rabbit muscle pyruvate kinase are not correlated with allosteric transitions.Effector analogues detect varied allosteric roles for conserved protein-effector interactions in pyruvate kinase isozymes.Functional energetic landscape in the allosteric regulation of muscle pyruvate kinase. 1. Calorimetric studyThe impact of ions on allosteric functions in human liver pyruvate kinase.Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.Probing the catalytic allosteric mechanism of rabbit muscle pyruvate kinase by tryptophan fluorescence quenching.Pyruvate-Kinase-Coupled Glycosyltransferase Assays: Limitations, Struggles and Problem Resolution.An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.Analyses of cobalt–ligand and potassium–ligand bond lengths in metalloproteins: trends and patterns
P2860
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P2860
Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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name
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@en
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@nl
type
label
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@en
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@nl
prefLabel
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@en
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@nl
P2093
P356
P1433
P1476
Differentiating a ligand's che ...... inhibition of pyruvate kinase.
@en
P2093
Aron W Fenton
Chunshan Gui
Gissel McDonald
Rachel Williams
Todd Holyoak
P304
P356
10.1021/BI0524262
P407
P577
2006-05-01T00:00:00Z