Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
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Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's diseaseTransfer of host-derived α synuclein to grafted dopaminergic neurons in ratNeuroprotective Activity of Hypericum perforatum and Its Major ComponentsThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesMitochondrial biology and Parkinson's diseaseProtein degradation pathways in Parkinson's disease: curse or blessingMorphological and metabolic changes in the nigro-striatal pathway of synthetic proteasome inhibitor (PSI)-treated rats: a MRI and MRS studySulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosisEnvironmental Exposures and Parkinson's DiseaseThe relationship between glucocerebrosidase mutations and Parkinson diseaseDopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's diseaseHeat shock protein responses to aging and proteotoxicity in the olfactory bulb.Heat shock proteins in neurodegenerative disorders and agingSelective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyBiomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesParkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeastLysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.Pros and cons of a prion-like pathogenesis in Parkinson's diseaseLow-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tStable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperonesMitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.Are there roles for brain cell senescence in aging and neurodegenerative disorders?NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusionsMelittin restores proteasome function in an animal model of ALSOxidative stress in neurodegenerative diseases.New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Autophagy in dementias.Biomarker candidates of neurodegeneration in Parkinson's disease for the evaluation of disease-modifying therapeuticsMolecular chaperones in Parkinson's disease--present and futureRoles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioningOxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.The Interplay between Alpha-Synuclein Clearance and Spreading
P2860
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P2860
Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@en
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@nl
type
label
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@en
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@nl
prefLabel
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@en
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@nl
P2093
P1476
Alterations in lysosomal and p ...... to alpha-synuclein inclusions.
@en
P2093
Hemraj Dodiya
Patrick Aebischer
Yaping Chu
P304
P356
10.1016/J.NBD.2009.05.023
P577
2009-06-06T00:00:00Z