Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
about
Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic ApproachesPresenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tauEarly life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease.Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease.Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention.Presenilin transgenic mice as models of Alzheimer's disease.Aβ40 has a subtle effect on Aβ42 protofibril formation, but to a lesser degree than Aβ42 concentration, in Aβ42/Aβ40 mixtures.Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.Alzheimer's disease sends the wrong signals--a perspective.Hereditary and sporadic forms of abeta-cerebrovascular amyloidosis and relevant transgenic mouse modelsPresenilin: RIP and beyond.Development and mechanism of γ-secretase modulators for Alzheimer's disease.Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.Potent amyloidogenicity and pathogenicity of Aβ43.γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer's Disease.A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease.GSK3beta activity modifies the localization and function of presenilin 1.
P2860
Q22241945-52DB09A7-E56E-4F92-840C-142CAE1C29ADQ24301886-4CF1CF6D-01B6-4CE2-A34E-2ADC5054294CQ28535293-87ED9B8D-AEAA-4403-A27F-DD6C8BF9D4FAQ30587668-D3F9A888-111D-43CF-950B-5946B3928FF9Q33427814-214F0915-33B8-410A-8244-EA976ACC6D42Q33515793-5FD3957A-CCED-4861-8E20-2351CBCC5CC4Q33726342-4091452D-67CA-4615-86EB-824646BA9C94Q34058840-FB03B289-BD5B-4103-8E56-9B9D1E7A92DBQ34078241-01C3796A-2F7C-4486-A9DF-EDB0B570FB1CQ34635580-583F9E87-0134-4CC7-99E3-190A3835DAE9Q36070202-901DBEF0-F7AC-4B84-85E5-3CA72BA75A27Q36481687-96386487-6075-4418-85A5-547998F2ACEFQ36827322-4675DDC8-8F0E-4854-B47B-AAD33D29B010Q37040616-A67E30D1-ADAF-4B61-8B5D-D9F46297114DQ37075276-89C883A3-9F59-41FA-8924-588ADBB8074EQ37081527-5C73C55B-9D43-4C7B-BF6F-32EB3EAAD30BQ37188278-666E093B-2C1F-455F-B8FD-D25692000B9FQ37219819-E396F564-BA28-4DD4-BE1F-0F2A3706D6EAQ38101383-383446C8-F7A3-4692-B451-B13FB19CFC93Q38230384-7E6A61EB-4E8F-4CE5-981C-0EDDC3C41D8DQ39513749-0B67B506-2D4D-44D2-9DA3-BDF26434120FQ39545955-19B41194-E80F-436F-B128-09E20A21309BQ40056954-EE7E7F71-13EC-460B-B1E4-D038D86A7412Q40083147-AA65FE40-2588-4CBC-98AF-CA6C9C35F5E7Q42674921-F8181F45-A072-46CD-8914-04F396CF769FQ46185330-3FFA7A69-C38E-4CFD-BD1B-5C8C36453A59Q46407728-163E46FD-A449-4713-83ED-08AD6F197020Q48449769-3E63F8B5-61A7-478C-8DFE-132522FD6547Q51798675-30B1EDB8-EDC6-4B0C-9772-B9D2FEBBA5CB
P2860
Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@en
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@nl
type
label
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@en
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@nl
prefLabel
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@en
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology.
@nl
P2093
P1476
Deletion of presenilin 1 hydro ...... exacerbated amyloid pathology
@en
P2093
Erica Peethumnongsin
Leonid Tarassishin
Verena Kallhoff
Yue-Ming Li
P304
P356
10.1523/JNEUROSCI.5384-05.2006
P407
P577
2006-04-01T00:00:00Z