about
The search for novel analgesics: targets and mechanismsHead-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targetingG Protein-Coupled Receptors in CancerSpecialized Functional Diversity and Interactions of the Na,K-ATPaseEndothelinStudying GPCR/cAMP pharmacology from the perspective of cellular structurePhysiology of the orexinergic/hypocretinergic system: a revisit in 2012International Union of Basic and Clinical Pharmacology. XCVIII. Histamine ReceptorsOpportunities for functional selectivity in GPCR antibodiesNovel GPCR paradigms at the μ-opioid receptorNuclear GPCRs in cardiomyocytes: an insider's view of β-adrenergic receptor signalingPositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsStructural Features for Functional Selectivity at Serotonin ReceptorsTargeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to DateLigand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-targetImpedance responses reveal β₂-adrenergic receptor signaling pluridimensionality and allow classification of ligands with distinct signaling profilesProteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connectionFunctional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO MutationVU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyStructure and function of serotonin G protein-coupled receptors.i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4.Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors.Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Estimation of ligand affinity constants for receptor states in functional studies involving the allosteric modulation of G protein-coupled receptors: implications for ligand bias.CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling.A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transferSmall molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cellsMapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?Discovery of regulators of receptor internalization with high-throughput flow cytometry.The serotonin 5-HT7 receptors: two decades of research.Ghrelin and motilin receptor agonists: time to introduce bias into drug design.The potential for selective pharmacological therapies through biased receptor signalingCharacterization of a prawn OA/TA receptor in Xenopus oocytes suggests functional selectivity between octopamine and tyramine
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Functional selectivity and biased receptor signaling.
@en
Functional selectivity and biased receptor signaling.
@nl
type
label
Functional selectivity and biased receptor signaling.
@en
Functional selectivity and biased receptor signaling.
@nl
prefLabel
Functional selectivity and biased receptor signaling.
@en
Functional selectivity and biased receptor signaling.
@nl
P356
P1476
Functional selectivity and biased receptor signaling.
@en
P2093
Terry Kenakin
P304
P356
10.1124/JPET.110.173948
P407
P577
2010-10-28T00:00:00Z