Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation.

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation.

Item
http://www.wikidata.org/entity/Q48676930
P2X ion channel receptors and inflammationPrecision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive AstrocytesImaging neuroinflammation in multiple sclerosis using TSPO-PETMolecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations.Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.Role of neuro-immunological factors in the pathophysiology of mood disorders.In vivo PET imaging of neuroinflammation in Alzheimer's disease.Imaging of microglial activation in MS using PET: Research use and potential future clinical application.The microglial ATP-gated ion channel P2X7 as a CNS drug target.P2X7 receptor antagonists: a patent review (2010-2015).Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease.Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.Recent Advances in CNS P2X7 Physiology and Pharmacology: Focus on Neuropsychiatric Disorders.Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation.Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO
P2860

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation.

Item
http://www.wikidata.org/entity/Q48676930
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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name
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@en
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@nl
type
label
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@en
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@nl
prefLabel
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@en
Synthesis and initial preclini ...... l tracer of neuroinflammation.
@nl
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Synthesis and initial preclini ...... l tracer of neuroinflammation.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921