P1855
Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signalingButein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo.Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells.Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells.Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation.Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells.Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways.Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation.Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells.Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivoButein up-regulates the expression of the π class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathwayInduction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress
P921
Q35511177-C18F7740-38C1-40CF-84B7-8C99663B9862Q35884596-A14C5109-4ADD-491C-B077-A79B2039540EQ36642318-58E2A905-FE7C-44EB-9FA4-A39EA155A93BQ38482740-C72A2D0A-4565-4C31-9609-C328141C384AQ38484894-CD6639CB-8312-45F2-8E5A-EA410CDCC869Q38493301-552BE421-7B96-47A6-8FB1-6324988CF2EFQ39425103-2D0DEA79-789B-4CF0-885C-6223F7DAEC50Q39431001-82BBFB9F-E909-410B-BB60-BF51ABCB3AC2Q39504369-6395BDC1-4C40-4485-BA6F-FEB28C894A56Q39611258-704EE930-A2F5-401B-9EC7-B3C5EFBC15AAQ39657991-D243AC0F-6BF3-44E2-AB65-152249FDE491Q43807119-534180D5-BA47-461E-8012-28822190A7EAQ82738017-C8D3C943-49E4-452C-92F0-8905BB2F96AFQ84646130-2826BED0-636E-4C97-A1A7-80D86F4AAE45Q85028432-149D21FF-9F06-4F26-A174-1B5ED92F8239
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Butein
@sh
Butein
@sr
Buteina
@es
butein
@en
بوتئین
@azb
بوتئین
@fa
紫铆因
@zh
type
label
Butein
@sh
Butein
@sr
Buteina
@es
butein
@en
بوتئین
@azb
بوتئین
@fa
紫铆因
@zh
altLabel
(E)-2',3,4,4'-terahydroxychalcone
@en
2',3,4,4'-Tetrahydroxychalcone
@en
3,4,2',4'-Tetrahydroxychalcone
@en
prefLabel
Butein
@sh
Butein
@sr
Buteina
@es
butein
@en
بوتئین
@azb
بوتئین
@fa
紫铆因
@zh
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C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O)O
P2063
LMPK12120111
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P232
P233
C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O
P234
1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
P235
AYMYWHCQALZEGT-ORCRQEGFSA-N
P2566
100.006.963