about
Photosystem II: evolutionary perspectivesCarotenoid oxidation in photosystem II.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Rapid formation of the stable tyrosyl radical in photosystem II.Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.Resolving intermediates in biological proton-coupled electron transfer: a tyrosyl radical prior to proton movement.The stable tyrosyl radical in photosystem II: why D?Copper(I/II), α/β-Synuclein and Amyloid-β: Menage à Trois?A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides.Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein.Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.The role of metal ions in amyloid formation: general principles from model peptides.Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.Similarities and differences of copper and zinc cations binding to biologically relevant peptides studied by vibrational spectroscopies.Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity.Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer's Disease?Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity.Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides.Metals and Alzheimer's disease.Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease.How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study.New insights into the coordination of Cu(II) by the amyloid-B 16 peptide from Fourier transform IR spectroscopy and isotopic labeling.pH-Dependent Cu(II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations.Modeling the Cu+ binding in the 1-16 region of the amyloid-β peptide involved in Alzheimer's disease.Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent.Beta-carotene redox reactions in photosystem II: electron transfer pathway.Metal-binding properties of the peptide APP170-188: a model of the ZnII-binding site of amyloid precursor protein (APP).Modeling copper binding to the amyloid-β peptide at different pH: toward a molecular mechanism for Cu reduction.Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28).Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins.Oxidative stress and the amyloid beta peptide in Alzheimer's disease.Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production.Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?Folding of the prion peptide GGGTHSQW around the copper(II) ion: identifying the oxygen donor ligand at neutral pH and probing the proximity of the tryptophan residue to the copper ion.Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2.Characterization of the ZnII binding to the peptide amyloid-beta1-16 linked to Alzheimer's disease.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
@en
ricercatore
@it
հետազոտող
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name
Peter Faller
@ast
Peter Faller
@en
Peter Faller
@es
Peter Faller
@nl
Peter Faller
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type
label
Peter Faller
@ast
Peter Faller
@en
Peter Faller
@es
Peter Faller
@nl
Peter Faller
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prefLabel
Peter Faller
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Peter Faller
@en
Peter Faller
@es
Peter Faller
@nl
Peter Faller
@sl
P1006
P214
P244
P1006
P106
P21
P214
P244
P31
P496
0000-0001-8013-0806
P734
P735
P7859
lccn-n81007079