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SMAD2;3:SMAD4:FOXH1:Activin Response ElementSMAD2;3:SMAD4:FOXO3:FoxO3a-binding ElementWWTR1:p-2S-SMAD2/3:SMAD4 [nucleoplasm]p-2S-SMAD2/3:SMAD4:TGIF:HDAC1p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2p-2S-SMAD2/3:SMAD4:SP1p-2S-SMAD2/3:SMAD4:MEN1p-2S-SMAD2/3:SMAD4:SKI/SKIL:NCORp-SMAD2/3:SMAD4:TRIM33p-2S-SMAD2/3:SMAD4:PARP1p-2S-SMAD2/3:SMAD4:PPM1AThe SMAD2/3:SMAD4 complex transfers to the nucleusPhospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXH1 binds Activin Response ElementPhospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elementsPhosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1; E2F4/5 and DP1/2SMAD2/3:SMAD4 heterotrimer binds SP1MEN1 binds SMAD2/3:SMAD4 heterotrimerSMAD2/3:SMAD4 complex positively regulates JUNB transcriptionSKI/SKIL binds SMAD complex; suppressing TGF-beta signalingUbiquitination of SKI/SKIL by RNF111/SMURF2TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleusTGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimerPARP1 binds SMAD2/3:SMAD4 heterotrimerPPM1A protein phosphatase binds phosphorylated SMAD2/3Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
P527
Q50255086-21579A0E-9574-478B-8522-1C5C1B0DE063Q50255089-6C7F9DEB-D591-4B27-B02B-ABB83C1F62FEQ50257929-CC3DD039-EDC3-4EA2-AC74-983E19238180Q50257930-EB354A6B-85AE-499C-B972-D616EAC06A6DQ50257935-781BBCB0-E749-4F17-B72C-386BEE10E0F1Q50257936-68370ACE-7245-4EF6-A479-81A40125E042Q50257938-11EA7546-B404-4244-A9E4-55E7B074B5E0Q50257941-06853452-6944-431F-8F18-F654D7FD81E2Q50257945-7330E96E-1BEF-4D58-BE80-38C2BC51CEA5Q50257954-A789E8DD-358E-4BB4-A0E2-98FD0596ED09Q50257957-40273AD1-4C47-43C0-80D0-C0633E31DC12Q50287873-D6166469-B855-4DBE-B281-1B970804B360Q50287874-61C777E0-3EF4-4477-943E-4B139569FEEEQ50287876-0A2B471D-2275-4932-9C93-E7C4272C72DFQ50290101-F78CC241-1BCE-4BCF-B669-E6252719C105Q50290111-3219F4A8-8938-4C2C-8355-04B0F8F74356Q50290114-8C6B7E4B-65E6-478E-B7FC-D2D9786C3523Q50290116-71A399D4-878F-4179-9244-D611CB24CC0AQ50290117-3E3FE857-7BAD-4E8F-BE99-504BE94AADE3Q50290118-15F649AF-2C9F-4F42-B62D-AE5FD3F4B115Q50290120-CB99ECD2-0354-4AE0-896D-30A07B76CFD0Q50290124-7CA05F78-ECD5-4E21-B33E-E8B64B7BEDFFQ50290137-F2132F9A-3691-43E0-AFD8-463062F27EB5Q50290138-79A3134F-9620-4991-9B98-5A3109392D60Q50290140-F4EA2C1B-D78B-47BE-9017-1444557759FAQ50290144-34445224-FF22-4C9F-BC7C-5B928CE6A552
P527
description
Macromolecular complex
@en
name
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
@en
type
label
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
@en
prefLabel
p-2S-SMAD2/3:SMAD4 [nucleoplasm]
@en
P3937
R-HSA-173511