about
GP1b-IX-V complex:activated thrombin (factor IIa)Factor IIa inhibitors (compounds):IIaactivated thrombin (factor IIa):SERPIND1thrombin:cleaved antithrombin IIIActivated thrombin; (ELANE)Thrombin:Proteinase-activated receptorsLigands of GPCRs that activate Gq/11Thrombin-mediated activation of Proteinase-activated receptorsThrombin binding to GP1b:IX:Vfactor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimerprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)factor V -> factor Va + factor V activation peptideprothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide Bfactor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptidesactivated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparinactivated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulinHeparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)Thrombin proteolyzes IGF:IGFBP3:ALSProteinase-activated receptors can bind thrombinFactor IIa inhibitors (peptide):IIaFactor IIa inhibitors (compounds) binds IIaFactor IIa inhibitors (peptide) binds IIa
P527
Q50259178-72014BE1-30A8-4200-A7DD-8F5115100960Q50259285-660FFEA3-AD00-4A59-9DDF-C545DD50FDBEQ50259287-15297662-DDC8-4AAE-AC5B-029C8A5421D4Q50259290-0F0468E3-3AA4-46D0-9F4F-E13E20E3650CQ50261428-104D1E77-E20C-4F94-AB2C-8C282758BDB0Q50272481-88545BA5-8D8E-41D6-9F58-DEC4782F4462Q50272949-8203BA3E-42C7-4E5C-B83D-D3979B9EBBC0Q50291073-AB8B1327-8C2B-4991-BFA3-B64DC0629561Q50291143-3BD49B52-78E0-4174-BDB5-91621268917CQ50291193-B7DDB9ED-F5B3-41CB-8424-97E585B8A85DQ50291196-5182AC88-A375-4CCB-B89F-1C16CA89A7F4Q50291206-2DA00016-80BA-4A06-A305-BCA7AA043171Q50291207-708723A3-2C51-4EBB-8AB0-F139146F0FFDQ50291209-67141703-B8B1-47AA-8380-62C309859078Q50291210-66D46A21-FCA4-4796-8E41-9D330185C4CBQ50291212-A77638A4-DCC8-4953-9D77-D4F46186E5EAQ50291216-901A947C-C1B4-4EC9-B034-2A17D63A86C3Q50291220-5001C77D-3CA5-4C97-9F8B-773090B2085CQ50291231-89A4D463-ED2F-4DB3-A4C0-DEDB52F22584Q50296763-396A9EE7-BDC9-4F5E-B5C5-ED49CD6F68EFQ50298279-CA79B0C8-B489-4DE8-A377-83AA34928B84Q56855888-88DB1568-D8A0-44E6-BCBB-D58791085FE4Q56858679-DBE6C2D6-BDA2-4A96-9121-4106954A06D6Q56858681-8847D690-03B9-42B2-B838-E11FC1F8B5BE
P527
description
Macromolecular complex
@en
name
activated thrombin (factor IIa)
@en
type
label
activated thrombin (factor IIa)
@en
prefLabel
activated thrombin (factor IIa)
@en
P3937
R-HSA-156786