ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs - Wikidata - awgldk - TriplyDB

ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

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Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

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Q45317564-93DD14A8-BF7B-4696-919E-E68ECEEF986A

P527

ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

http://www.wikidata.org/entity/Q50295843

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An instance of the biological ...... f target mRNAs in Homo sapiens

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biologisch proces

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ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

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ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

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ZFP36 (Tristetraproline; TTP) binds AU-rich elements in 3' UTR of target mRNAs

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Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements

Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases

RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein.

A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay.

Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation.

Selective RNA binding by a single CCCH zinc-binding domain from Nup475 (Tristetraprolin).

Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates.

RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs.

Tristetraprolin recruits functional mRNA decay complexes to ARE sequences.

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reactome:R-HSA-450400

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biological process

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Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

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R-HSA-450400

http://www.w3.org/2001/XMLSchema#string

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ZFP36 ring finger protein

TTP:mRNA Complex

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