p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A - Wikidata - awgldk - TriplyDB

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

http://www.wikidata.org/entity/Q50295874

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Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

P527

Q45317575-C29DF904-5A02-455B-BE4E-FA5B5C6A5BD8

P527

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

http://www.wikidata.org/entity/Q50295874

description

An instance of the biological ...... CP1A; and PP2A in Homo sapiens

@en

biologisch proces

@nl

name

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

@en

type

label

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

@en

prefLabel

p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2A

@en

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Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

Structural basis of the PNRC2-mediated link between mrna surveillance and decapping

How and where are nonsense mRNAs degraded in mammalian cells?

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reactome:R-HSA-927813

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biological process

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Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

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R-HSA-927813

http://www.w3.org/2001/XMLSchema#string

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SMG6 nonsense mediated mRNA decay factor

Decapping mRNA 1A

SMG7 nonsense mediated mRNA decay factor

SMG5 nonsense mediated mRNA decay factor

Proline rich nuclear receptor coactivator 2

PP2A (Aalpha:B55alpha:Calpha)

SMG1:Phosphorylated UPF1:EJC:Translated mRNP

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP

P703