SMO translocates to the cilium - Wikidata - awgldk - TriplyDB

SMO translocates to the cilium

SMO translocates to the cilium

http://www.wikidata.org/entity/Q50298961

about

Activation of SMO

P527

Q45318280-01F02A37-B9E6-4386-8D22-F60AE0401BCE

P527

SMO translocates to the cilium

http://www.wikidata.org/entity/Q50298961

description

An instance of the biological reaction SMO translocates to the cilium in Homo sapiens

@en

biologisch proces

@nl

name

SMO translocates to the cilium

@en

type

label

SMO translocates to the cilium

@en

prefLabel

SMO translocates to the cilium

@en

P2860

Q50298961-0B774D1C-8637-4A99-945F-19638BB7C1FE

Q50298961-1F79FFE6-4772-428E-8054-6E7792019B8E

Q50298961-396D4977-A9B9-4BB8-A053-B7CB5F7D0A4A

Q50298961-415D9CF0-AA9B-4619-A71C-6958FC949A7B

Q50298961-51CF642C-6649-475A-90AC-C73F8CC6EBC6

Q50298961-60AE0269-0F60-4588-9B14-E35952C1C9F6

Q50298961-6DF1A297-A620-4839-A977-26EC658EA0C6

Q50298961-777E23AB-525C-44E0-9303-3BCBBF564618

Q50298961-7DDCF865-D8F2-444F-9138-0181591BF48E

Q50298961-812DB800-7670-4D8F-A8D2-85AE2F27E36D

P2888

Q50298961-2D14A87D-2EB8-4228-B693-8CB001B13E65

P31

Q50298961-6BAC147A-2922-4149-87B8-70A3B7A5EFFA

P361

Q50298961-D8A453AA-B4C2-43FD-9A5A-D095BAABA2C4

P3937

Q50298961-DDAD404E-2920-43CD-B185-D3B6E2408A04

P527

Q50298961-598FA1A1-380B-4EC7-8E5F-AFFB457C9DB2

Q50298961-90606A52-0145-4573-B94A-4F7DED3A47A7

Q50298961-98E3545B-2AA0-408B-B5B1-FF719AC54AA9

Q50298961-AA720BB1-858D-4CDC-808B-C0AAE4D8A8CD

Q50298961-AE45C8F9-D53B-4BAA-901E-21D5AC2669D5

Q50298961-D092C9F9-77BB-433D-B237-81353172C1F3

Q50298961-E0D5AF08-231D-492E-9049-399CC3E81FAF

P703

Q50298961-9BD36982-7AF5-4E70-A0E8-8B2A975FB82D

P2860

GRK2: multiple roles beyond G protein-coupled receptor desensitization

Vertebrate Smoothened functions at the primary cilium.

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

Patched1 regulates hedgehog signaling at the primary cilium

EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

Hedgehog regulates smoothened activity by inducing a conformational switch.

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

P2888

reactome:R-HSA-5632668

P31

biological process

P361

Activation of SMO

P3937

R-HSA-5632668

http://www.w3.org/2001/XMLSchema#string

P527

Growth arrest specific 8

Hh-Npp:BOC:PTCH1

Hh-Npp:CDON:PTCH

Hh-Npp:GAS1:PTCH

SMO dimer:ARRB:KIF3A

SMO dimer [ciliary membrane]

P703