The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.
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CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosisSanguinarine suppresses prostate tumor growth and inhibits survivin expressionAltered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosisSurvivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesSurvivin - biology and potential as a therapeutic target in oncologyIn vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin BMLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with BorealinLocalization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell.Targeting the UPS as therapy in multiple myeloma.Selenium inhibition of survivin expression by preventing Sp1 binding to its promoterEGF regulates survivin stability through the Raf-1/ERK pathway in insulin-secreting pancreatic β-cells.Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markersTargeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells.SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.Possible protective effect of membrane lipid rafts against interleukin-1β-mediated anti-proliferative effect in INS-1 cells.Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosisUbiquitin-proteasomal degradation of antiapoptotic survivin facilitates induction of apoptosis in prostate cancer cells by pristimerin.The basic helix-loop-helix transcription factor Nex-1/Math-2 promotes neuronal survival of PC12 cells by modulating the dynamic expression of anti-apoptotic and cell cycle regulators.Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism.Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1.Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation.Function of survivin in trophoblastic cells of the placenta.The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin.Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model.Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death.Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis.Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro.Transformation, translation and TRAIL: an unexpected intersection.Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia.Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.DARPP32, STAT5 and STAT3 mRNA expression ratios in glioblastomas are associated with patient outcome.A single amino acid change (Asp 53 --> Ala53) converts Survivin from anti-apoptotic to pro-apoptotic
P2860
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P2860
The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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name
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@en
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@nl
type
label
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@en
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@nl
prefLabel
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@en
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@nl
P2093
P1476
The ubiquitin-proteasome pathw ...... a cell cycle-dependent manner.
@en
P2093
P304
P407
P478
P577
2000-12-01T00:00:00Z