about
The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiationIdentification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycanUcma, a novel secreted cartilage-specific protein with implications in osteogenesisProteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilageChanges in proteasome structure and function caused by HAMLET in tumor cells.Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13.Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C.The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q.Altered osteoclast development and function in osteopontin deficient mice.Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry.OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation.The C-terminal peptide of chondroadherin modulates cellular activity by selectively binding to heparan sulfate chains.Elucidating the Molecular Composition of Cartilage by Proteomics.The tyrosine sulfate-rich domains of the LRR proteins fibromodulin and osteoadherin bind motifs of basic clusters in a variety of heparin-binding proteins, including bioactive factors.Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (cartilage oligomeric matrix protein).Biomarkers and proteomic analysis of osteoarthritis.The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: a preclinical study.The minor collagens in articular cartilage.Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.Cartilage oligomeric matrix protein neoepitope in the synovial fluid of horses with acute lameness: A new biomarker for the early stages of osteoarthritis.Correction: The Skeletal Phenotype of Chondroadherin Deficient Mice.The C-terminal domain of chondroadherin: a new regulator of osteoclast motility counteracting bone loss.Nanomechanical phenotype of chondroadherin-null murine articular cartilage.Fragmentation of proteins in cartilage treated with interleukin-1: specific cleavage of type IX collagen by matrix metalloproteinase 13 releases the NC4 domain.Binding mitochondria to cryogel monoliths allows detection of proteins specifically released following permeability transition.Cartilage matrix remodelling differs by disease state and joint type.Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment.Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays.Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system.Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B.Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβQuantitative proteomics at different depths in human articular cartilage reveals unique patterns of protein distributionLink N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activityCalbindin D28k Exhibits Properties Characteristic of a Ca2+ SensorHigh sample throughput flow immunoassay utilising restricted access columns for the separation of bound and free labelTargeted proteomics of hip articular cartilage in OA and fracture patients
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P50
description
onderzoeker
@nl
researcher
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հետազոտող
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name
Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
@nl
Patrik Onnerfjord
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type
label
Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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Patrik Onnerfjord
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P1053
R-3131-2019
P106
P108
P1153
6601966697
P31
P3829
P496
0000-0002-2345-2937