Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.
about
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationshipsCatalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteriaStructure-activity relationship studies of the two-component lantibiotic haloduracinCyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptidesSalivaricin P, one of a family of two-component antilisterial bacteriocins produced by intestinal isolates of Lactobacillus salivarius.Dissecting structural and functional diversity of the lantibiotic mersacidinProduction of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13Synthesis of trypsin-resistant variants of the Listeria-active bacteriocin salivaricin PGeneration of an actagardine A variant library through saturation mutagenesis.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Isolation and characterization of bacteriocin-producing bacteria from the intestinal microbiota of elderly Irish subjects.Investigating the importance of charged residues in lantibiotics.A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.Bactofencin A, a new type of cationic bacteriocin with unusual immunity.Characterization of amylolysin, a novel lantibiotic from Bacillus amyloliquefaciens GA1.Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactateAssessing the combinatorial potential of the RiPP cyanobactin tru pathwayProduction of multiple bacteriocins from a single locus by gastrointestinal strains of Lactobacillus salivarius.Homologues and bioengineered derivatives of LtnJ vary in ability to form D-alanine in the lantibiotic lacticin 3147.Extensive manipulation of caseicins A and B highlights the tolerance of these antimicrobial peptides to change.Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tractStructural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium.Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.The importance of the leader sequence for directing lanthionine formation in lacticin 481.Expanding role of lipid II as a target for lantibiotics.Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR.Engineering unnatural variants of plantazolicin through codon reprogramming.Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases.Follow the leader: the use of leader peptides to guide natural product biosynthesis.Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V.Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147.Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activityFundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides.The dawning of a 'Golden era' in lantibiotic bioengineering.Increasing the success rate of lantibiotic drug discovery by Synthetic Biology.Antimicrobial mechanism of lantibiotics.Peptide antimicrobials: cell wall as a bacterial target.
P2860
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P2860
Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
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2006年學術文章
@zh-hant
name
Complete alanine scanning of t ...... rint for rational drug design.
@en
Complete alanine scanning of t ...... rint for rational drug design.
@nl
type
label
Complete alanine scanning of t ...... rint for rational drug design.
@en
Complete alanine scanning of t ...... rint for rational drug design.
@nl
prefLabel
Complete alanine scanning of t ...... rint for rational drug design.
@en
Complete alanine scanning of t ...... rint for rational drug design.
@nl
P2093
P2860
P50
P1476
Complete alanine scanning of t ...... print for rational drug design
@en
P2093
Elaine M Lawton
Lorraine A Draper
Lucy H Deegan
Paula M O'Connor
P2860
P304
P356
10.1111/J.1365-2958.2006.05398.X
P407
P577
2006-11-01T00:00:00Z