UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

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UGT genotyping in belinostat dosing Pharmacogenomics and histone deacetylase inhibitors.In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes.

P2860

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P2860

UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

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http://www.wikidata.org/entity/Q50546142

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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name

UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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type

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UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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UGT1A1 genotype-dependent dose ...... netic modeling and simulation.

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P1476

UGT1A1 genotype-dependent dose ...... inetic modeling and simulation

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P2093

Cody J Peer

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Jane B Trepel

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Min-Jung Lee

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Richard Piekarz

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Sheryl Erlich

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Susan E Bates

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Tristan M Sissung

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William D Figg

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Yusuke Tomita

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P2860

Monitoring the effect of belinostat in solid tumors by H4 acetylation

Ways to fit a PK model with some data below the quantification limit.

Likelihood based approaches to handling data below the quantification limit using NONMEM VI.

A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours

A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study.

Handling data below the limit of quantification in mixed effect models.

Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome.

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors.

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.

P304

450-460

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scholarly article

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10.1002/JCPH.627

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Sanjeeve Balasubramaniam

Andrew K L Goey

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2015-12-04T00:00:00Z

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285734422

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26637161

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6357964

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UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

about

P2860

P2860

UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

description

name

type

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P1433

P1476

P2093

P2860

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