about
Synergistic applications of MD and NMR for the study of biological systemsLipid-mediated interactions between intrinsic membrane proteins: dependence on protein size and lipid compositionEfficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method.Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors.Peroxidase activity and involvement in the oxidative stress response of roseobacter denitrificans truncated hemoglobin.tRNAGlu increases the affinity of glutamyl-tRNA synthetase for its inhibitor glutamyl-sulfamoyl-adenosine, an analogue of the aminoacylation reaction intermediate glutamyl-AMP: mechanistic and evolutionary implications.The influenza fusion peptide adopts a flexible flat V conformation in membranes.Quinazoline-4-piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathological mineralization of valve interstitial cells.Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties.Membrane Assembly and Ion Transport Ability of a Fluorinated NanoporeSynthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity.Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations.The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness.Theoretical investigations of nitric oxide channeling in Mycobacterium tuberculosis truncated hemoglobin N.Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water.Molecular dynamics of class A β-lactamases-effects of substrate binding.The influenza fusion peptide promotes lipid polar head intrusion through hydrogen bonding with phosphates and N-terminal membrane insertion depth.Determining the mode of action involved in the antimicrobial activity of synthetic peptides: a solid-state NMR and FTIR study.Correction: tRNAGlu Increases the Affinity of Glutamyl-tRNA Synthetase for Its Inhibitor Glutamyl-Sulfamoyl-Adenosine, an Analogue of the Aminoacylation Reaction Intermediate Glutamyl-AMP: Mechanistic and Evolutionary Implications.TEM-1 backbone dynamics-insights from combined molecular dynamics and nuclear magnetic resonance.Aeromonas salmonicida Ati2 is an effector protein of the type three secretion system.Molecular dynamics simulations of the influenza hemagglutinin fusion peptide in micelles and bilayers: conformational analysis of peptide and lipids.Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs.Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations.Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N.Effect of Saturated Very Long-Chain Fatty Acids on the Organization of Lipid Membranes: A Study Combining (2)H NMR Spectroscopy and Molecular Dynamics Simulations.Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1.Implementing a web-based introductory bioinformatics course for non-bioinformaticians that incorporates practical exercises.Extended Linkers Improve the Detection of Protein-protein Interactions (PPIs) by Dihydrofolate Reductase Protein-fragment Complementation Assay (DHFR PCA) in Living Cells.Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.
P50
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P50
description
chercheur et professeur d'université
@fr
researcher and university professor
@en
wetenschapper
@nl
name
Patrick Lagüe
@ast
Patrick Lagüe
@en
Patrick Lagüe
@fr
Patrick Lagüe
@nl
type
label
Patrick Lagüe
@ast
Patrick Lagüe
@en
Patrick Lagüe
@fr
Patrick Lagüe
@nl
prefLabel
Patrick Lagüe
@ast
Patrick Lagüe
@en
Patrick Lagüe
@fr
Patrick Lagüe
@nl
P108
P1153
6701707690
P2038
Patrick_Laguee
P21
P31
P496
0000-0002-5236-4979
P6634
patrick-lagüe-a581385a