Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors.

Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors.

Item
http://www.wikidata.org/entity/Q50727408
A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol.Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.Elucidation of the molecular basis of cholecystokinin Peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modelingSensitivity of cholecystokinin receptors to membrane cholesterol content.Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: use of cell lines with elevated cholesterol.Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor.Structural basis of cholecystokinin receptor binding and regulation.Direct demonstration of unique mode of natural peptide binding to the type 2 cholecystokinin receptor using photoaffinity labeling.Environmentally sensitive fluorescent sensors based on synthetic peptides.
P2860

Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors.

Item
http://www.wikidata.org/entity/Q50727408
description
2006 nî lūn-bûn
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2006年の論文
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name
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@en
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@nl
type
label
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@en
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@nl
prefLabel
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@en
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Fluorescent indicators distrib ...... d B cholecystokinin receptors.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921