Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.
about
Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cordMorphogen rules: design principles of gradient-mediated embryo patterningRoles for Hedgehog signaling in adult organ homeostasis and repairLanguage Impairments in ASD Resulting from a Failed Domestication of the Human BrainA theoretical framework for the regulation of Shh morphogen-controlled gene expressionMorphogens, modeling and patterning the neural tube: an interview with James Briscoe.Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cellsSox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo.Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signalingIdentification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site DensityTcf7l2/Tcf4 Transcriptional Repressor Function Requires HDAC Activity in the Developing Vertebrate CNSA direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressorsNeural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional ProgramsSoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signalsUnderstanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2.An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.Generating spinal motor neuron diversity: a long quest for neuronal identity.Transcriptional regulation of graded Hedgehog signalingHedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.Decoding of position in the developing neural tube from antiparallel morphogen gradients.Crosstalk between SOXB1 proteins and WNT/β-catenin signaling in NT2/D1 cells.Cooperation and crosstalk in axon guidance cue integration: Additivity, synergy, and fine-tuning in combinatorial signaling.Su(H)-mediated repression positions gene boundaries along the dorsal-ventral axis of Drosophila embryos.Morphogen interpretation: concentration, time, competence, and signaling dynamicsSpatiotemporal regulation of GLI target genes in the mammalian limb bud.Arx together with FoxA2, regulates Shh floor plate expression.Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution.Retinoic Acid Induces Ubiquitination-Resistant RIP140/LSD1 Complex to Fine-Tune Pax6 Gene in Neuronal DifferentiationDistinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells.Detailed expression analysis of regulatory genes in the early developing human neural tube.SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types.GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis-van Creveld syndrome.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.SOX2 regulates common and specific stem cell features in the CNS and endoderm derived organs.Differential Cellular Responses to Hedgehog Signalling in Vertebrates-What is the Role of Competence?
P2860
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P2860
Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Mechanistic differences in the ...... range Shh morphogen signaling.
@en
Mechanistic differences in the ...... range Shh morphogen signaling.
@nl
type
label
Mechanistic differences in the ...... range Shh morphogen signaling.
@en
Mechanistic differences in the ...... range Shh morphogen signaling.
@nl
prefLabel
Mechanistic differences in the ...... range Shh morphogen signaling.
@en
Mechanistic differences in the ...... range Shh morphogen signaling.
@nl
P2093
P50
P1433
P1476
Mechanistic differences in the ...... range Shh morphogen signaling.
@en
P2093
Christopher W Uhde
Jonas Muhr
José M Dias
Maria Bergsland
Sanja Kurdija
Tony Oosterveen
P304
P356
10.1016/J.DEVCEL.2012.09.015
P407
P577
2012-11-01T00:00:00Z