Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers. - Wikidata - awgldk - TriplyDB

Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.

Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.

http://www.wikidata.org/entity/Q50855321

about

Histone H2A/H2B chaperones: from molecules to chromatin-based functions in plant growth and development Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.FACT is a sensor of DNA torsional stress in eukaryotic cells.Level of FACT defines the transcriptional landscape and aggressive phenotype of breast cancer cells.Prognostic value of histone chaperone FACT subunits expression in breast cancer.Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer.Wild type p53 reactivation: from lab bench to clinic.The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations.Quantitative interactome analysis reveals a chemoresistant edgotype.Structural analysis of nucleosomal barrier to transcription FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497 Pharmacological reactivation of p53 as a strategy to treat cancer.Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on both mRNA and protein levels in human cells Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation."Naked" FACT is unstable.Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy.Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation.Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas.SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway.TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells.Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.Role of chromatin damage and chromatin trapping of FACT in mediating the anticancer cytotoxicity of DNA-binding small molecule drugs.Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants.Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

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Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.

http://www.wikidata.org/entity/Q50855321

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

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name

Facilitates chromatin transcri ...... target of aggressive cancers.

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Facilitates chromatin transcri ...... target of aggressive cancers.

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type

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Facilitates chromatin transcri ...... target of aggressive cancers.

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Facilitates chromatin transcri ...... target of aggressive cancers.

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prefLabel

Facilitates chromatin transcri ...... target of aggressive cancers.

@en

Facilitates chromatin transcri ...... target of aggressive cancers.

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J.CELREP.2013.06.013

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Facilitates chromatin transcri ...... target of aggressive cancers.

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P2093

Alfiya Safina

http://www.w3.org/2001/XMLSchema#string

Angela R Omilian

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Anja Ruusulehto

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Carl Morrison

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Henry Garcia

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Jeffrey C Miecznikowski

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Jianmin Wang

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Katerina V Gurova

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Kristopher Attwood

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Mairead Commane

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P2860

Model-based analysis of ChIP-Seq (MACS)

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication

FACT facilitates chromatin transcription by RNA polymerases I and III

Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1

FACT facilitates transcription-dependent nucleosome alteration

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

An Oct4-centered protein interaction network in embryonic stem cells

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.

Modulation of SRF-dependent gene expression by association of SPT16 with MKL1.

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