Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
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Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217AStabilization of the E* Form Turns Thrombin into an AnticoagulantRigidification of the autolysis loop enhances Na+ binding to thrombinMolecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype.Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shearEngineering thrombin for selective specificity toward protein C and PAR1.Characterization of human platelet binding of recombinant T cell receptor ligand.The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner.WEDGE: an anticoagulant thrombin mutant produced by autoactivation.Allostery in trypsin-like proteases suggests new therapeutic strategies.Thrombin.Design of Factor XIII V34X activation peptides to control ability to interact with thrombin mutants.Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).Rational Design of Protein C Activators.Proteases as therapeutics.Utility of microfluidic devices to study the platelet-endothelium interface.Long range communication between exosites 1 and 2 modulates thrombin function.Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis.Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib.
P2860
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P2860
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@en
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@nl
type
label
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@en
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@nl
prefLabel
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@en
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.
@nl
P2093
P1476
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist
@en
P2093
Enrico Di Cera
Erik I Tucker
Leslie A Bush-Pelc
Michelle A Berny
Owen J T McCarty
Tara C White
P304
P356
10.1161/ATVBAHA.107.156273
P407
P577
2007-10-25T00:00:00Z