Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells.
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Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysisβ-cell dedifferentiation in diabetes is important, but what is it?Tolbutamide stimulation of pancreatic beta-cells involves both cell recruitment and increase in the individual Ca(2+) responseRenin release and gene expression in intact rat kidney microvessels and single cellsGlucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cellHomologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse.Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase.Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes.Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells.Scaffold architecture controls insulinoma clustering, viability, and insulin production.Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretionOn-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells.Rapid and reversible secretion changes during uncoupling of rat insulin-producing cellsRepeated glucose stimulation reveals distinct and lasting secretion patterns of individual rat pancreatic B cells.Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancyMafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.Low insulin content of large islet population is present in situ and in isolated islets.Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo.A Unifying Organ Model of Pancreatic Insulin Secretion.Rat basophilic leukemia cells stiffen when they secreteNewly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.Adequate connexin-mediated coupling is required for proper insulin production.Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assayBeta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes.Connexin36 and pancreatic beta-cell functions.The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation.Heterogeneous expression of glucokinase among pancreatic beta cells.Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.Protein-mediated interactions of pancreatic islet cellsSingle pancreatic beta cells co-express multiple islet hormone genes in mice.MiRNAs in β-Cell Development, Identity, and Disease.Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes.Connexins: key mediators of endocrine function.Minireview: intraislet regulation of insulin secretion in humans.The gap junction: a channel for multiple functions?Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Beta cell connectivity in pancreatic islets: a type 2 diabetes target?
P2860
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P2860
Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年学术文章
@wuu
1986年学术文章
@zh
1986年学术文章
@zh-cn
1986年学术文章
@zh-hans
1986年学术文章
@zh-my
1986年学术文章
@zh-sg
1986年學術文章
@yue
1986年學術文章
@zh-hant
name
Heterogeneity and contact-depe ...... cretion by individual B cells.
@en
Heterogeneity and contact-depe ...... cretion by individual B cells.
@nl
type
label
Heterogeneity and contact-depe ...... cretion by individual B cells.
@en
Heterogeneity and contact-depe ...... cretion by individual B cells.
@nl
prefLabel
Heterogeneity and contact-depe ...... cretion by individual B cells.
@en
Heterogeneity and contact-depe ...... cretion by individual B cells.
@nl
P1476
Heterogeneity and contact-depe ...... cretion by individual B cells.
@en
P2093
P304
P356
10.1016/0014-4827(86)90354-X
P407
P577
1986-02-01T00:00:00Z