Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

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http://www.wikidata.org/entity/Q50950249
Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.The S1 helix critically regulates the finely tuned gating of Kv11.1 channelsSchizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput ScreeningUbiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.Getting to the heart of hERG K(+) channel gating.hERG quality control and the long QT syndrome.Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel.The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress-the role of cysteine residues in the alpha interacting domain.Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels.
P2860

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

Item
http://www.wikidata.org/entity/Q50950249
description
2013 nî lūn-bûn
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Trafficking defects in PAS dom ...... ed domain-domain interactions.
@en
Trafficking defects in PAS dom ...... ed domain-domain interactions.
@nl
type
label
Trafficking defects in PAS dom ...... ed domain-domain interactions.
@en
Trafficking defects in PAS dom ...... ed domain-domain interactions.
@nl
prefLabel
Trafficking defects in PAS dom ...... ed domain-domain interactions.
@en
Trafficking defects in PAS dom ...... ed domain-domain interactions.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Trafficking defects in PAS dom ...... red domain-domain interactions
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698