about
High-yield anaerobic succinate production by strategically regulating multiple metabolic pathways based on stoichiometric maximum in Escherichia coliEngineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli.Engineering microorganisms based on molecular evolutionary analysis: a succinate production case studyMetabolic engineering of Escherichia coli for the production of riboflavin.Engineering of acetate recycling and citrate synthase to improve aerobic succinate production in Corynebacterium glutamicum.Multiplex iterative plasmid engineering for combinatorial optimization of metabolic pathways and diversification of protein coding sequences.Establishment of a markerless mutation delivery system in Bacillus subtilis stimulated by a double-strand break in the chromosome.Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity.Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering.Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing.Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering.Production of Acetoin through Simultaneous Utilization of Glucose, Xylose, and Arabinose by Engineered Bacillus subtilis.Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity.Metabolic engineering of Escherichia coli for poly(3-hydroxybutyrate) production via threonine bypassFluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells.Aroma improvement by repeated freeze-thaw treatment during Tuber melanosporum fermentation.Collaborative regulation of CO2 transport and fixation during succinate production in Escherichia coli.Integrating metabolomics into a systems biology framework to exploit metabolic complexity: strategies and applications in microorganisms.Metabolic engineering of Bacillus subtilis for chiral pure meso-2,3-butanediol production.Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidineGenome shuffling: Progress and applications for phenotype improvement.Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenationIsolation and characterization of polysaccharides with the antitumor activity from Tuber fruiting bodies and fermentation system.Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure D-2,3-butanediol production.Optimization of riboflavin production by recombinant Bacillus subtilis RH44 using statistical designs.Purification and functional characterization of thermostable 5-aminolevulinic acid synthases.Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis.Strain improvement of Sporolactobacillus inulinus ATCC 15538 for acid tolerance and production of D-lactic acid by genome shuffling.Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli.Directed pathway evolution of the glyoxylate shunt in Escherichia coli for improved aerobic succinate production from glycerol.Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions.In silico metabolic engineering of Bacillus subtilis for improved production of riboflavin, Egl-237, (R,R)-2,3-butanediol and isobutanol.Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum.Comparative transcriptome analysis for metabolic engineering.Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production.Improved succinate production in Corynebacterium glutamicum by engineering glyoxylate pathway and succinate export system.A synthetic microbial consortium of Shewanella and Bacillus for enhanced generation of bioelectricity.Expression of galactose permease and pyruvate carboxylase in Escherichia coli ptsG mutant increases the growth rate and succinate yield under anaerobic conditions.Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid.
P50
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P50
description
researcher, Tianjin University, ORCID: 0000-0001-9588-1821
@en
name
Tao Chen
@ast
Tao Chen
@en
Tao Chen
@es
Tao Chen
@nl
Tao Chen
@sl
type
label
Tao Chen
@ast
Tao Chen
@en
Tao Chen
@es
Tao Chen
@nl
Tao Chen
@sl
prefLabel
Tao Chen
@ast
Tao Chen
@en
Tao Chen
@es
Tao Chen
@nl
Tao Chen
@sl
P106
P31
P496
0000-0001-9588-1821