A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
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CRTH2 expression on T cells in asthma.Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects.Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responsesTwo Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthmaEfficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies.Prostaglandin D₂ and T(H)2 inflammation in the pathogenesis of bronchial asthma.Emerging drugs for asthma.Polyunsaturated Fatty Acid-derived lipid mediators and T cell function.The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases.Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459.Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases.Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma.Human eosinophils and mast cells: Birds of a feather flock together.A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.The prostaglandin D receptor 2 pathway in asthma: a key player in airway inflammation
P2860
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P2860
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
A dominant role for chemoattra ...... nse to mast cell supernatants.
@en
A dominant role for chemoattra ...... e expressed on T helper type 2
@nl
type
label
A dominant role for chemoattra ...... nse to mast cell supernatants.
@en
A dominant role for chemoattra ...... e expressed on T helper type 2
@nl
prefLabel
A dominant role for chemoattra ...... nse to mast cell supernatants.
@en
A dominant role for chemoattra ...... e expressed on T helper type 2
@nl
P2093
P2860
P1433
P1476
A dominant role for chemoattra ...... nse to mast cell supernatants.
@en
P2093
Elizabeth R Townsend
Frank Wettey
Luzheng Xue
Roy Pettipher
Shân L Gyles
P2860
P304
P356
10.1111/J.1365-2567.2006.02440.X
P577
2006-11-01T00:00:00Z