Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.
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Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis.IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes.The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid MiceDeficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance, and altered cathelicidin antimicrobial Peptide.Targeting the pancreatic β-cell to treat diabetes.Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes.Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms.Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency.
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P2860
Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.
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name
Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@en
Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@nl
type
label
Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@en
Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
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Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@en
Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@nl
P2093
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Interleukin-15 plays an essent ...... une diabetes in the NOD mouse.
@en
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J Stankova
S Ilangumaran
S Ramanathan
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P2888
P304
P356
10.1007/S00125-012-2675-1
P577
2012-08-14T00:00:00Z