about
Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations.The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils.Contrasting disease and nondisease protein aggregation by molecular simulationHomogeneous and heterogeneous tertiary structure ensembles of amyloid-β peptides.A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data.Kinetics of amyloid beta monomer-to-oligomer exchange by NMR relaxation.Protein folding by distributed computing and the denatured state ensemble.Automated sequence- and stereo-specific assignment of methyl-labeled proteins by paramagnetic relaxation and methyl-methyl nuclear Overhauser enhancement spectroscopy.Characterizing methyl-bearing side chain contacts and dynamics mediating amyloid β protofibril interactions using ¹³C(methyl)-DEST and lifetime line broadening.Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase IIProbing exchange kinetics and atomic resolution dynamics in high-molecular-weight complexes using dark-state exchange saturation transfer NMR spectroscopy.Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Influence of denatured and intermediate states of folding on protein aggregationDetermining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide.A coarse-grained alpha-carbon protein model with anisotropic hydrogen-bonding.Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.How hot? Systematic convergence of the replica exchange method using multiple reservoirs.Optimization of DsRed production in Escherichia coli: effect of ribosome binding site sequestration on translation efficiency.Synthesis and Characterization of a Magnetically Active 19F Molecular Beacon.Probing the Atomic Structure of Transient Protein Contacts by Paramagnetic Relaxation Enhancement Solution NMR.Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment.A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.Coarse-grained simulations of protein aggregation.Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus.Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.TDP-43 α-helical structure tunes liquid-liquid phase separation and functionMolecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domainThe (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Nicolas L Fawzi
@ast
Nicolas L Fawzi
@en
Nicolas L Fawzi
@es
Nicolas L Fawzi
@nl
Nicolas L Fawzi
@sl
type
label
Nicolas L Fawzi
@ast
Nicolas L Fawzi
@en
Nicolas L Fawzi
@es
Nicolas L Fawzi
@nl
Nicolas L Fawzi
@sl
prefLabel
Nicolas L Fawzi
@ast
Nicolas L Fawzi
@en
Nicolas L Fawzi
@es
Nicolas L Fawzi
@nl
Nicolas L Fawzi
@sl
P1053
E-2555-2013
P106
P21
P31
P3829
P496
0000-0001-5483-0577