Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. - Wikidata - awgldk - TriplyDB

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.

http://www.wikidata.org/entity/Q51353898

about

Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator?Multidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticides Carboxylesterase1/Esterase-x regulates chylomicron production in mice ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment.Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion.Hepatic trans-Golgi action coordinated by the GTPase ARFRP1 is crucial for lipoprotein lipidation and assembly.Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.Oxidative Stress Attenuates Lipid Synthesis and Increases Mitochondrial Fatty Acid Oxidation in Hepatoma Cells Infected with Hepatitis C Virus.Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury.Ces3/TGH Deficiency Attenuates Steatohepatitis Hepatic fatty acid trafficking: multiple forks in the road Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.RNA-seq based detection of differentially expressed genes in the skeletal muscle of Duroc pigs with distinct lipid profiles.Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.Carboxylesterases in lipid metabolism: from mouse to human.Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.Effects of eicosapentaenoic acid on hepatic dyslipidemia and oxidative stress in high fat diet-induced steatosis.Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia.Functionalized bis-enol acetates as specific molecular probes for esterases.Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr -/- mice.Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis.Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD.Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate How sweet it is to activate FXR Breed Differences in Pig Liver Esterase (PLE) between Tongcheng (Chinese Local Breed) and Large White Pigs

P2860

Q26995818-4F1E4C15-4D7F-4414-8D1C-B8B2E0C5C21C Q28387124-86878286-0CF9-49BC-A6C6-15D219913069 Q28484918-7FE9AEC8-616C-4396-9C81-0AD97882BB06 Q33729901-0FA71758-31C6-4876-B585-C11158BB2FDA Q33823338-45FFD784-D0C7-4EF0-8D2D-31EC0C1D674D Q33858526-AC03E448-A34A-4336-BE1A-875854A3ADE2 Q34382248-97911192-030A-4A6F-9420-761CB548320C Q34611588-E3D30F66-2095-4EEC-B298-031EF207C25E Q34730646-6066477A-FEA8-440C-92F2-49342EA4A246 Q35074176-A65493B7-26E0-4B5D-9CE0-90B17C1D824A Q35152098-F9F44F48-7048-45C7-8A2E-B67E3B55970F Q35304688-6969D18A-7476-43CE-BE5A-EBEE1146CE37 Q36489340-98324AE8-6B0C-4057-BED1-7905EA16B2B2 Q36591276-B5FCB8EB-32A5-4B7B-B8F9-F879D7AFDE64 Q36796372-2F5FD078-9C08-465C-BA12-434CFC58EC43 Q36903024-003465AA-93A2-475E-8927-D87D6266CFA6 Q37296476-41A92970-F942-45DE-BF4B-08AEFD0F06F9 Q37607992-C3585AE0-39B2-4981-8BC3-B4D213621136 Q37611624-69A12166-A6E3-4073-8D94-24DC05DD5ADF Q37640198-5CDD016E-1F9C-4587-ADD0-8852F21EAEDD Q38425828-ACA4A414-EAFB-4ACC-B484-404AACE5B3E6 Q39414484-A42E5F17-4F57-4C4D-9AB7-6ACB174C5E96 Q40076014-B6786283-4133-43B0-99FD-6228EA032F95 Q40897100-8629E9EA-A00F-41E1-9FA0-6902A467BDAD Q41108866-C2907E8C-71CA-489D-A587-9ED5ABD47F08 Q41974559-89591780-0DE6-4C4B-955D-8BB085EEBBA9 Q41986445-F7E04993-D389-44C6-905C-5D071B7A83B2 Q42581495-B6D3B176-A7DD-4767-B02D-A5CFEBD8F7B1 Q44842786-0CD4D1B1-31E4-4A8F-8DB4-D884B5E46603 Q47132750-9CB0440E-3E66-4AF6-BBF2-5BB820881665 Q49809354-03E3AD30-0C20-47F6-BACE-112DB4BC9DC7 Q52691185-6104F9A9-4ADF-4576-8E6B-586802D628C2 Q55001888-D7C2AD27-63CF-491C-BD6F-BDA533096AE6 Q57112884-1F5BD1B5-1A5A-4A59-9FCA-9F531F99B11D Q57152662-5A6D9405-A9DF-4B61-9D34-95C00A183136 Q58612377-82868947-EE72-4F22-BFE3-FDF062141815

P2860

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia.

http://www.wikidata.org/entity/Q51353898

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh-hant

name

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@en

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@nl

type

label

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@en

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@nl

prefLabel

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@en

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@nl

P1433

Q51353898-1698E759-2711-426C-92DA-EC2640B36744

P1476

Q51353898-8C14C9CF-20B3-4354-9596-E1BFDAA6CAED

P2093

Q51353898-58DFB833-46D5-49F7-AB2B-19A7C326FF4A

Q51353898-6FDD5F29-B108-4621-ADA3-4C072B53A8B3

Q51353898-DD3E2A1F-0317-4A40-BAA9-D96A060ACC2B

Q51353898-E590B9DB-96A8-4DA3-8B3E-C1C72F89A2EF

Q51353898-F57E0459-A1E8-449D-A258-7877C477B29A

P2860

Q51353898-086B0A14-E5DC-497C-81FC-195B8BB4B082

Q51353898-0ABF67AB-8BC4-4FE5-A388-D27AD9D2EB9F

Q51353898-163BCECE-88DA-4183-BB01-49B012F24DA7

Q51353898-254F0E09-4357-4A38-9B97-01381A625271

Q51353898-3961F499-E75F-462D-8D3F-24F60A2F0421

Q51353898-3B0D4E62-10F5-4382-9B7E-1D7F59B19E0A

Q51353898-4E246332-D0C6-403A-B4D6-DD686A720BDA

Q51353898-52A8311E-4781-459D-91F6-F30A5A62D53F

Q51353898-7226C76A-3147-491D-9BBD-D7E70796C81B

Q51353898-80B9EB20-DE0C-4C81-868D-46ADAC0D8AB1

P304

Q51353898-32E37206-DC8A-43C7-B9CA-0308E510BC92

P31

Q51353898-519F359F-A1B4-4C81-B6E1-6E295751A795

P356

Q51353898-7EB871DB-A0D3-45D8-A789-247C9079376D

P407

Q51353898-82633A15-7F45-4917-B8BE-B89BDA856248

P433

Q51353898-95C181E3-8253-4E34-9A83-219CC5B31206

P478

Q51353898-9E7D7CEB-4A0D-4B8E-9E61-B2A4ED6073F0

P50

Q51353898-0206C72A-4EED-4B1D-99F7-6150327B0BF1

Q51353898-6EFDEDA3-6586-4DFF-A2D8-062775870E6F

Q51353898-D4B0B097-B066-4B0B-A1F8-C4D866289915

P577

Q51353898-F798E4D4-4D01-49C1-A834-AA43C70CE43C

P5875

Q51353898-1CC7528E-F2E7-4FC1-9E28-C2A933CC9F5E

P698

Q51353898-93A0E598-D5D8-4F87-A268-D52E54589380

P921

Q51353898-BABD9BDA-4F27-4980-947B-C44B0DC8F3AD

Q51353898-D4AD48E3-A97E-44D9-BA1C-7759A6231A9C

P356

P1433

P1476

Deficiency of carboxylesterase ...... steatosis, and hyperlipidemia.

@en

P2093

Ariel D Quiroga

http://www.w3.org/2001/XMLSchema#string

Harald Köfeler

http://www.w3.org/2001/XMLSchema#string

Lena Li

http://www.w3.org/2001/XMLSchema#string

Randy Nelson

http://www.w3.org/2001/XMLSchema#string

Richard Lehner

http://www.w3.org/2001/XMLSchema#string

P2860

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure

Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay.

Free fatty acids and pathogenesis of type 2 diabetes mellitus.

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.

Triacylglycerol hydrolase: role in intracellular lipid metabolism.

Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C-II.

Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease.

The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism.

Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes.

P304

2188-2198

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/HEP.25961

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

56

http://www.w3.org/2001/XMLSchema#string

P50

Spencer Proctor

Harald Köfeler

Martin Trötzmüller

P577

2012-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

229160721

http://www.w3.org/2001/XMLSchema#string

P698

22806626

http://www.w3.org/2001/XMLSchema#string

P921