Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example.
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesChemoprevention of Breast Cancer by Dietary PolyphenolsStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewSystems genetics for drug target discoveryQuantitative modeling of dose–response and drug combination based on pathway networkA network-based multi-target computational estimation scheme for anticoagulant activities of compoundsDrug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavirA Network-Based Target Overlap Score for Characterizing Drug Combinations: High Correlation with Cancer Clinical Trial ResultsSystems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General CaseTinnitus: network pathophysiology-network pharmacology.Reducing in fl uenza spreading over the airline network.Chemogenomic profiling predicts antifungal synergies.Confidence from uncertainty--a multi-target drug screening method from robust control theory.Predicting targeted drug combinations based on Pareto optimal patterns of coexpression network connectivityCross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazoleAn update on the strategies in multicomponent activity monitoring within the phytopharmaceutical fieldCritical paths in a metapopulation model of H1N1: Efficiently delaying influenza spreading through flight cancellation.Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.Structure-based systems biology for analyzing off-target bindingEvaluation of a topical herbal drug for its in-vivo immunomodulatory effect on cytokines production and antibacterial activity in bovine subclinical mastitis.The role of the interactome in the maintenance of deleterious variability in human populationsControl of asymmetric Hopfield networks and application to cancer attractorsBiomolecular self-defense and futility of high-specificity therapeutic targeting.Cellular networks and the aging process.Platelet aggregation pathway network-based approach for evaluating compounds efficacy.The prince and the pauper. A tale of anticancer targeted agents.Traditional Knowledge of Western Herbal Medicine and Complex Systems ScienceSystems biology and cancer prevention: all options on the table.Advancing genetic theory and application by metabolic quantitative trait loci analysis.A strategy based on protein-protein interface motifs may help in identifying drug off-targets.Traditional herbal remedies that influence cell adhesion molecule activity.How to design multi-target drugs.Biological networks and drug discovery--where do we stand?Weak-binding molecules are not drugs?-toward a systematic strategy for finding effective weak-binding drugs.Computational approaches for innovative antiepileptic drug discovery.Insights into the inhibition and mechanism of compounds against LPS-induced PGE2 production: a pathway network-based approach and molecular dynamics simulations.Pathway-focused bioassays and transcriptome analysis contribute to a better activity monitoring of complex herbal remedies.Utility of network integrity methods in therapeutic target identification.Inferring multi-target QSAR models with taxonomy-based multi-task learning.High-order combination effects and biological robustness
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P2860
Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Multiple weak hits confuse com ...... ulatory network as an example.
@en
Multiple weak hits confuse com ...... ulatory network as an example.
@nl
type
label
Multiple weak hits confuse com ...... ulatory network as an example.
@en
Multiple weak hits confuse com ...... ulatory network as an example.
@nl
prefLabel
Multiple weak hits confuse com ...... ulatory network as an example.
@en
Multiple weak hits confuse com ...... ulatory network as an example.
@nl
P2093
P2860
P1433
P1476
Multiple weak hits confuse com ...... ulatory network as an example.
@en
P2093
Péter Csermely
Sándor Pongor
Vilmos Agoston
P2860
P304
P356
10.1103/PHYSREVE.71.051909
P407
P433
P577
2005-05-26T00:00:00Z
P698
P818
q-bio/0410026