about
Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disordersA lipid switch unlocks Parkinson's disease-associated ATP13A2Unlocking ATP13A2/PARK9 activityRegulation of endoplasmic reticulum Ca(2+) oscillations in mammalian eggs.The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.Transmembrane helix 11 is a genuine regulator of the endoplasmic reticulum Ca2+ pump and acts as a functional parallel of β-subunit on α-Na+,K+-ATPase.Ca2+ induces spontaneous dephosphorylation of a novel P5A-type ATPase.Modulating sarco(endo)plasmic reticulum Ca2+ ATPase 2 (SERCA2) activity: cell biological implications.DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store.New perspectives on the role of SERCA2's Ca2+ affinity in cardiac function.Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump.A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.Factors controlling the activity of the SERCA2a pump in the normal and failing heart.The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.Towards defining the substrate of orphan P5A-ATPases.Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness.Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2.Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases.The expression of the neonatal sarcoplasmic reticulum Ca2+ pump (SERCA1b) hints to a role in muscle growth and development.Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.Modeling Ca2+ dynamics of mouse cardiac cells points to a critical role of SERCA's affinity for Ca2+.Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.Ca2+ transport ATPase isoforms SERCA2a and SERCA2b are targeted to the same sites in the murine heart.ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells.Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps.Parkinson disease related ATP13A2 evolved early in animal evolution.Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a).SPCA2 couples Ca2+ influx via Orai1 to Ca2+ uptake into the Golgi/secretory pathway.Time-Dependent Protein Thermostability Assay.Targeting sarcoplasmic reticulum Ca2+ uptake to improve heart failure: hit or miss.Cardiomyocyte Overexpression of Neuronal Nitric Oxide Synthase Delays Transition Toward Heart Failure in Response to Pressure Overload by Preserving Calcium CyclingCa2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads onlyTight interplay between the Ca2+ affinity of the cardiac SERCA2 Ca2+ pump and the SERCA2 expression levelA SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life spanPhospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²⁺ homeostasis but not Ca²⁺-dependent hypertrophic signalingHigh-throughput measurement of the Ca2+-dependent ATPase activity in COS microsomesMeasuring Ca2+-dependent Ca2+-uptake activity in the mouse heartMeasuring Ca2+ pump activity in overexpression systems and cardiac muscle preparationsStructures of the heart specific SERCA2a Ca2+-ATPase
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Peter Vangheluwe
@ast
Peter Vangheluwe
@en
Peter Vangheluwe
@es
Peter Vangheluwe
@nl
Peter Vangheluwe
@sl
type
label
Peter Vangheluwe
@ast
Peter Vangheluwe
@en
Peter Vangheluwe
@es
Peter Vangheluwe
@nl
Peter Vangheluwe
@sl
prefLabel
Peter Vangheluwe
@ast
Peter Vangheluwe
@en
Peter Vangheluwe
@es
Peter Vangheluwe
@nl
Peter Vangheluwe
@sl
P1053
P-5476-2017
P106
P1153
6506524209
P21
P31
P3829
P496
0000-0002-7822-2944