Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
about
Priming GPCR signaling through the synergistic effect of two G proteins.Synergistic Use of GPCR Modeling and SDM Experiments to Understand Ligand Binding.Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2A ligand binding kinetics.Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines.A kinetic view of GPCR allostery and biased agonism.Biochemical and Pharmacological Role of A1 Adenosine Receptors and Their Modulation as Novel Therapeutic Strategy.
P2860
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P2860
Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
description
2016 nî lūn-bûn
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2016年の論文
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
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2016年学术文章
@zh-my
2016年学术文章
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2016年學術文章
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2016年學術文章
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name
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@en
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@nl
type
label
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@en
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@nl
prefLabel
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@en
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy.
@nl
P2093
P2860
P50
P356
P1476
Extracellular Loop 2 of the Ad ...... Affinity and Agonist Efficacy
@en
P2093
Anh T N Nguyen
Jo-Anne Baltos
Karen J Gregory
Laura López Muñoz
Lauren T May
Paul J White
Toan D Nguyen
P2860
P304
P356
10.1124/MOL.116.105007
P577
2016-09-28T00:00:00Z