about
Mechanisms of alveolar epithelial injury, repair, and fibrosisAbsence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosisActivation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoterPulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis.Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbationsProteinase-activated receptors in fibroproliferative lung disease.Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection.Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infantsEnhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.BARD1 mediates TGF-β signaling in pulmonary fibrosis.Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae.Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury.Molecular targets in pulmonary fibrosis: the myofibroblast in focus.Coagulation signalling following tissue injury: focus on the role of factor Xa.Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.Evidence for chemokine synergy during neutrophil migration in ARDSThe pathogenesis of pulmonary fibrosis: a moving target.Coagulation and coagulation signalling in fibrosis.The mercurial nature of neutrophils: still an enigma in ARDS?Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathwaysAltered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cellsThe anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome.Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosisProtease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.Role of a functional polymorphism in the F2R gene promoter in sarcoidosis.Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats.Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models.Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch.Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis.
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P50
description
hulumtuese
@sq
onderzoeker
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researcher
@en
հետազոտող
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name
Rachel C Chambers
@nl
Rachel C Chambers
@sl
Rachel C. Chambers
@en
Rachel C. Chambers
@es
type
label
Rachel C Chambers
@nl
Rachel C Chambers
@sl
Rachel C. Chambers
@en
Rachel C. Chambers
@es
prefLabel
Rachel C Chambers
@nl
Rachel C Chambers
@sl
Rachel C. Chambers
@en
Rachel C. Chambers
@es
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0000-0003-1370-9417