The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction.
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A polycystin-centric view of cyst formation and disease: the polycystins revisitedMouse models of ciliopathies: the state of the art.Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesisPkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1Stepwise unfolding of ankyrin repeats in a single protein revealed by atomic force microscopy.Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.Identification of a mechanical rheostat in the hydrophobic core of protein L.Receptor protein tyrosine phosphatases are novel components of a polycystin complexMechanical unfolding of an ankyrin repeat protein.Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Molecular diagnostics for autosomal dominant polycystic kidney diseaseNaturally occurring osmolytes modulate the nanomechanical properties of polycystic kidney disease domainsComplex folding kinetics of a multidomain protein.Effect of PKD1 gene missense mutations on polycystin-1 membrane topogenesis.Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathwayPolycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein StabilityElevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severityGenetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.The isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling.Quantifying cardiovascular flow dynamics during early development.Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.Analysis of the REJ Module of Polycystin-1 Using Molecular Modeling and Force-Spectroscopy TechniquesGrowth of cranial synchondroses and sutures requires polycystin-1.Visualizing myosin-actin interaction with a genetically-encoded fluorescent strain sensor.Polycystic kidney disease and the renal cilium.The nanomechanics of polycystin-1 extracellular region.Defining features of the hair cell mechanoelectrical transducer channelNaturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains.Emerging evidence of a link between the polycystins and the mTOR pathways.Polycystins and renovascular mechanosensory transduction.Polycystins, focal adhesions and extracellular matrix interactionsCalcium channels in primary cilia.Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.Biophysics and Biofluiddynamics of Primary Cilia: evidence for and against the flow-sensing function.Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.Non-native interactions are critical for mechanical strength in PKD domains.The Roles of Primary cilia in Polycystic Kidney Disease.Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis.Mechanical unfolding revisited through a simple but realistic model.
P2860
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P2860
The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
The remarkable mechanical stre ...... t role in mechanotransduction.
@en
The remarkable mechanical stre ...... t role in mechanotransduction.
@nl
type
label
The remarkable mechanical stre ...... t role in mechanotransduction.
@en
The remarkable mechanical stre ...... t role in mechanotransduction.
@nl
prefLabel
The remarkable mechanical stre ...... t role in mechanotransduction.
@en
The remarkable mechanical stre ...... t role in mechanotransduction.
@nl
P2093
P1476
The remarkable mechanical stre ...... t role in mechanotransduction.
@en
P2093
Jane Clarke
Julia R Forman
Richard N Sandford
Seema Qamar
P304
P356
10.1016/J.JMB.2005.04.008
P407
P577
2005-06-01T00:00:00Z