An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.
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A Thermally Stable Form of Bacterial Cocaine Esterase: A Potential Therapeutic Agent for Treatment of Cocaine AbuseStructural analysis of thermostabilizing mutations of cocaine esteraseCocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaineSubunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence TimePressure- and heat-induced inactivation of butyrylcholinesterase: evidence for multiple intermediates and the remnant inactivation processButyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behaviorSymbiotic relationship of pharmacogenetics and drugs of abuse.Modeling of pharmacokinetics of cocaine in human reveals the feasibility for development of enzyme therapies for drugs of abusePredicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.Physiologic and metabolic safety of butyrylcholinesterase gene therapy in miceComputational redesign of human butyrylcholinesterase for anticocaine medication.Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users.Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCatalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaineDevelopment of organophosphate hydrolase activity in a bacterial homolog of human cholinesteraseThe ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometryCatalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.Pharmacogenetics of analgesic drugsChemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo.Cocaine Hydrolase Gene Transfer Demonstrates Cardiac Safety and Efficacy against Cocaine-Induced QT Prolongation in MiceProspects, promise and problems on the road to effective vaccines and related therapies for substance abuseInterception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users.Cocaine hydrolase gene therapy for cocaine abuseHuman butyrylcholinesterase-cocaine binding pathway and free energy profiles by molecular dynamics and potential of mean force simulations.Recombinant human butyrylcholinesterase as a new-age bioscavenger drug: development of the expression system.Modeling evolution of hydrogen bonding and stabilization of transition states in the process of cocaine hydrolysis catalyzed by human butyrylcholinesterase.Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants.Fundamental reaction mechanism for cocaine hydrolysis in human butyrylcholinesterasePlant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivityPseudo-cholinesterase polymorphism in Mazandaran province (North of Iran).Active site gating and substrate specificity of butyrylcholinesterase and acetylcholinesterase: insights from molecular dynamics simulations.
P2860
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P2860
An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@en
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@nl
type
label
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@en
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@nl
prefLabel
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@en
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@nl
P2093
P356
P1476
An improved cocaine hydrolase: ...... rase is 4-fold more efficient.
@en
P2093
P356
10.1124/MOL.55.1.83
P577
1999-01-01T00:00:00Z