Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
about
Peptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of actionMolecular basis of Pirh2-mediated p53 ubiquitylationAcetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitroOverexpression of RAD51 occurs in aggressive prostatic cancerHuman cancer protein-protein interaction network: a structural perspectiveSpecific recognition of p53 tetramers by peptides derived from p53 interacting proteinsPredicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning.The central region of HDM2 provides a second binding site for p53.Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damageInhibiting HIV-1 integrase by shifting its oligomerization equilibriumRAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defectsLessons in Protein Design from Combined Evolution and Conformational Dynamics.Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.Hub promiscuity in protein-protein interaction networks.The relevance of protein-protein interactions for p53 function: the CPE contribution.A novel oncoprotein Pirh2: rising from the shadow of MDM2.Using peptides to study protein-protein interactions.The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.Choosing where to look next in a mutation sequence space: Active Learning of informative p53 cancer rescue mutants.Structural and functional implications of p53 missense cancer mutations.Nuclear Localization Signal and p53 Binding Site in MAP/ERK Kinase Kinase 1 (MEKK1)Identification of transient hub proteins and the possible structural basis for their multiple interactions.Acetylation of the p53 DNA-binding domain regulates apoptosis induction.Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations.Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.Rigid-body motions of interacting proteins dominate multispecific binding of ubiquitin in a shape-dependent manner.Characterization of an Hsp90-Independent Interaction between Co-Chaperone p23 and Transcription Factor p53.Effects of oncogenic mutations and DNA response elements on the binding of p53 to p53-binding protein 2 (53BP2).Mutational analysis of the p53 core domain L1 loop.Multiple drugs and multiple targets: an analysis of the electrostatic determinants of binding between non-nucleoside HIV-1 reverse transcriptase inhibitors and variants of HIV-1 RT.Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy
P2860
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P2860
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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2004年學術文章
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name
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@en
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@nl
type
label
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@en
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@nl
prefLabel
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@en
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@nl
P2093
P2860
P356
P1476
Binding of Rad51 and other pep ...... trostatic binding site in p53.
@en
P2093
Assaf Friedler
Karoly I von Glos
Trevor Rutherford
P2860
P304
P356
10.1074/JBC.M411176200
P407
P577
2004-12-20T00:00:00Z