Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.
about
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionRecent developments in using mechanistic cardiac modelling for drug safety evaluationIntegrating Multiscale Modeling with Drug Effects for Cancer TreatmentImplementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical ResearchAgent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivityMetabolomics and systems pharmacology: why and how to model the human metabolic network for drug discoveryA Dormant Microbial Component in the Development of PreeclampsiaThe promises of quantitative systems pharmacology modelling for drug developmentAlgorithmic modeling quantifies the complementary contribution of metabolic inhibitions to gemcitabine efficacyCombined model of intrinsic and extrinsic variability for computational network design with application to synthetic biologyLeveraging systems biology approaches in clinical pharmacologyCPT: Pharmacometrics and Systems PharmacologyEffect of disease states on α1 -adrenoceptor binding and signal transduction parameters in isolated perfused heart: quantification by pharmacokinetic-pharmacodynamic modelling.Integrating experimentation and quantitative modeling to enhance discovery of Beta amyloid lowering therapeutics for Alzheimer's disease.From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine.Towards Quantitative Systems Pharmacology Models of Chemotherapy-Induced Neutropenia.Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.Model-based dietary optimization for late-stage, levodopa-treated, Parkinson's disease patients.Inferring biochemical reaction pathways: the case of the gemcitabine pharmacokinetics.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic PopulationsSystems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities.A novel systems pharmacology model for herbal medicine injection: a case using Reduning injection.Implementation of quantitative and systems pharmacology in large pharma.Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection modelPredicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modellingBridging the gap between in vitro and in vivo: Dose and schedule predictions for the ATR inhibitor AZD6738Molecular mechanism matters: Benefits of mechanistic computational models for drug development.Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease.A combined model reduction algorithm for controlled biochemical systemsEnhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.Systems pharmacology-based approach for dissecting the active ingredients and potential targets of the Chinese herbal Bufei Jianpi formula for the treatment of COPD.Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Parsing interindividual drug variability: an emerging role for systems pharmacology.A model qualification method for mechanistic physiological QSP models to support model-informed drug development.Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models.System biology analysis of long-term effect and mechanism of Bufei Yishen on COPD revealed by system pharmacology and 3-omics profilingA Six-Stage Workflow for Robust Application of Systems Pharmacology.Quantitative Systems Pharmacology: A Framework for Context.Merging systems biology with pharmacodynamics.
P2860
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P2860
Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Systems pharmacology: bridging ...... rug discovery and development.
@en
Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics
@nl
type
label
Systems pharmacology: bridging ...... rug discovery and development.
@en
Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics
@nl
prefLabel
Systems pharmacology: bridging ...... rug discovery and development.
@en
Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics
@nl
P2860
P1476
Systems pharmacology: bridging ...... rug discovery and development.
@en
P2093
Neil Benson
Piet H van der Graaf
P2860
P304
P356
10.1007/S11095-011-0467-9
P577
2011-05-11T00:00:00Z