Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.
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A discrete alcohol pocket involved in GIRK channel activationStructure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogasterThe Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSHGeneral anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channelG-protein-coupled inwardly rectifying potassium channels are targets of alcohol actionAlcohol inhibits cell-cell adhesion mediated by human L1Do gap junctions play a role in nerve transmissions as well as pacing in mouse intestine?Ethanol and protein kinase C.Ethanol actions on multiple ion channels: which are important?Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivityThe significance of interstitial cells in neurogastroenterologyThe mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse.Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesiaGeneral anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.Mechanisms of alcohol-induced tissue injury.Molecular mapping of general anesthetic sites in a voltage-gated ion channel.Butanol isomers exert distinct effects on voltage-gated calcium channel currents and thus catecholamine secretion in adrenal chromaffin cells.Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational AnestheticsAlkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.Molecular features of an alcohol binding site in a neuronal potassium channel.Novel activation of voltage-gated K(+) channels by sevoflurane.The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanolsDistinct sensitivity of slo1 channel proteins to ethanol.Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channelsCaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channelsA site of alcohol action in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor.Ammonia blockade of intestinal epithelial K+ conductance.Fatty acid ethyl esters, nonoxidative metabolites of ethanol, accelerate the kinetics of activation of the human brain delayed rectifier K+ channel, Kv1.1.Single-channel basis for conductance increase induced by isoflurane in Shaker H4 IR K(+) channels.Ethanol-sensitive sites on the human dopamine transporter.Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate.L-type Ca2+ channel and ryanodine receptor cross-talk in frog skeletal muscle.Dynamic changes in the osmotic water permeability of protoplast plasma membrane.Paradoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons.Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.Modulation of two cloned potassium channels by 1-alkanols demonstrates different cutoffs.Interaction of alcohols and anesthetics with protein kinase Calpha.Primary alcohols modulate the activation of the G protein-coupled receptor rhodopsin by a lipid-mediated mechanism.Regulation of adenylyl cyclase isoforms by N-alkanols.
P2860
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P2860
Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@en
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@nl
type
label
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@en
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@nl
prefLabel
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@en
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@nl
P2093
P2860
P356
P1476
Alcohols inhibit a cloned pota ...... r basis of general anesthesia.
@en
P2093
P2860
P304
19408-19416
P356
10.1074/JBC.270.33.19408
P407
P577
1995-08-01T00:00:00Z