Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.
about
A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membraneCoupling of the nucleus and cytoplasm: role of the LINC complexStructural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffnessMammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processesMyotonic dystrophy protein kinase is critical for nuclear envelope integrityhMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cellsThe nuclear lamina is mechano-responsive to ECM elasticity in mature tissueThe nuclear envelope: an intriguing focal point for neurogenetic diseaseNuclear deformability and telomere dynamics are regulated by cell geometric constraints.Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments.Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner.Nuclear migration events throughout developmentHeading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical EnvironmentsLaminopathies and the long strange trip from basic cell biology to therapyAbnormal nuclear shape and impaired mechanotransduction in emerin-deficient cellsNuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migrationLamin A/C and emerin are critical for skeletal muscle satellite cell differentiationLMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic miceMonoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482WThe effect of the lamin A and its mutants on nuclear structure, cell proliferation, protein stability, and mobility in embryonic cellsEvolution of the lamin protein family: what introns can tell.Cancer biomarker discovery: the entropic hallmark.Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton.Transient nuclear envelope rupturing during interphase in human cancer cells.The tethering of chromatin to the nuclear envelope supports nuclear mechanics.Nonlinear osmotic properties of the cell nucleus.Lamin A/C is a risk biomarker in colorectal cancer.Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.Diseases of the nuclear envelope.Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans.Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation.Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy.The lamin protein family."Laminopathies": a wide spectrum of human diseases.Inner nuclear membrane proteins: impact on human disease.Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophiesPrelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.
P2860
Q24292716-404F03A8-7097-4683-8ED3-0479FDCFC82FQ24299991-5ECCB836-43DE-4B30-B954-DFF8D0BAFED0Q24318372-49B4A16E-BCF7-4783-BDDC-C49A502677BBQ24319820-F3DD613E-9796-4F09-AF1A-092B0E1ECEADQ24338683-35EE1286-4751-44CD-805A-D1A27DF0FC78Q24529984-FB4B0FEA-974B-44C2-9BDE-AF83F1FC65E5Q26859120-ECCABC39-62B9-4F17-8B6A-F56E17B08E02Q27006719-9D1CFC02-62BF-4C31-B335-64DDAF65076BQ27319957-67FE046F-2802-4AB8-B418-A1D1537B2610Q27334775-44E0DA7F-3BCC-41E6-8762-7F182B747C41Q27348514-6264FE0A-FA73-49E8-A3FB-1AA776C6A337Q28070084-2B25539F-2FC3-4D5B-8D23-A85DBE81497DQ28072132-E620881B-53D5-4ECD-89EF-0CA3A3371118Q28251294-B114B306-8A86-4E11-84E9-2F113ECF57BEQ28268495-E81DF70F-19DA-4768-AA89-4E82AC93FB36Q28505944-BB4E3B8A-20EE-43F4-AC4E-19FFFFF7C720Q28511959-1A90817C-61D0-47AE-BB62-93416FB770CCQ28594207-0CEDB5A3-F1CC-4E4C-ACDF-444449865B9DQ28752198-7C4918BD-8926-44DB-A425-A702C39EAB16Q28910340-1E99B512-0741-4682-AC55-B3449EB8B995Q30410501-71267B7F-22B2-4DBD-A564-2994BB7E13CBQ30496149-A9CBF83F-471A-4F7D-99A5-D5EDBBAB7D81Q30497830-3C1C1597-6F18-4A59-9FB2-BDFA411DD22BQ30502842-F9D1F3D3-7B09-403E-A100-42CD57BF921EQ30513945-0B1F7905-F597-4362-9A2B-64FA15520576Q30656516-729E50FD-D18E-41AF-BC84-F0F5D9A3D0E9Q30856192-09601CC8-FF47-433A-A4F8-F25E0B705071Q33361579-01F3AA44-54CF-48A1-9CCD-139244264100Q33551452-40F892E7-AB3D-4CC3-9B05-EB7577DE8EBAQ33687043-CDED71FC-C3C5-4225-8753-CAE5607A3C14Q33739566-E07BD312-0AFE-46F9-BFB3-C7A6902483BAQ33741805-8B51C577-BE1B-408C-A1B6-98CB0C44E708Q33954299-2F5BC498-AD7D-42BE-B99C-32EF58A27F64Q34015228-EDEECB25-B34A-4592-8274-485C56FDD620Q34189692-D9AE077E-788C-4324-AA19-A3E6054C5E9FQ34242119-86BF512D-B195-4D49-B48C-10FE2EC37456Q34252203-F57EC415-4A59-4D29-A66A-1C289FAD71E5Q34399213-9984DF64-6AE2-464C-80CE-6111BB38C5D7Q34457223-949ABFAF-7669-4C91-A5A8-DA09678C838FQ34521711-3D85FEEF-E190-4845-A17E-F823684742E2
P2860
Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Decreased mechanical stiffness ...... development of laminopathies.
@en
Decreased mechanical stiffness ...... development of laminopathies.
@nl
type
label
Decreased mechanical stiffness ...... development of laminopathies.
@en
Decreased mechanical stiffness ...... development of laminopathies.
@nl
prefLabel
Decreased mechanical stiffness ...... development of laminopathies.
@en
Decreased mechanical stiffness ...... development of laminopathies.
@nl
P2093
P356
P1476
Decreased mechanical stiffness ...... development of laminopathies.
@en
P2093
Carlijn V C Bouten
Cees W J Oomens
Emiel A G Peeters
Frank P T Baaijens
Frans C S Ramaekers
Helma J H Kuijpers
Jorike Endert
Jos L V Broers
P304
P356
10.1093/HMG/DDH295
P577
2004-09-14T00:00:00Z