about
Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acidsThe action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1The Concise Guide to PHARMACOLOGY 2013/14: overview.Application of BRET to monitor ligand binding to GPCRs.Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.Functional homomers and heteromers of dopamine D2L and D3 receptors co-exist at the cell surfaceFragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.G protein-coupled receptors for free fatty acids.Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ)Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells.Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization.Constitutive activity of GPR40/FFA1 intrinsic or assay dependent?Fluorescent ligands for G protein-coupled receptors: illuminating receptor-ligand interactions for drug discovery.Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs.Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells.A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.Binding kinetics of ligands acting at GPCRsFluorescent ligands: Bringing light to emerging GPCR paradigmsSingle molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Leigh A Stoddart
@ast
Leigh A Stoddart
@en
Leigh A Stoddart
@es
Leigh A Stoddart
@nl
Leigh A Stoddart
@sl
type
label
Leigh A Stoddart
@ast
Leigh A Stoddart
@en
Leigh A Stoddart
@es
Leigh A Stoddart
@nl
Leigh A Stoddart
@sl
prefLabel
Leigh A Stoddart
@ast
Leigh A Stoddart
@en
Leigh A Stoddart
@es
Leigh A Stoddart
@nl
Leigh A Stoddart
@sl
P106
P31
P496
0000-0002-4469-0600