Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

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Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†An improved purification method for the lysosomal storage disease protein β-glucuronidase produced in CHO cells.

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Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Evaluation of butyrate-induced ...... me using parallel bioreactors.

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Chikkathur N Madhavarao

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Cyrus D Agarabi

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Gibbes R Johnson

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Howard Anderson

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Lily Wong

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Mansoor Khan

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Sven Müller-Loennies

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Thomas Braulke

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P2860

Mannose 6-phosphate receptors: new twists in the tale

Identification of N-glycans displaying mannose-6-phosphate and their site of attachment on therapeutic enzymes for lysosomal storage disorder treatment.

Identification of novel small molecule enhancers of protein production by cultured mammalian cells.

Common and uncommon pathogenic cascades in lysosomal storage diseases

Beta glucuronidase deficiency: report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis.

Enzyme replacement for lysosomal diseases.

Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice

Sorting of lysosomal proteins.

Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest.

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184-192

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scholarly article

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10.1002/BAB.1151

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2014-02-20T00:00:00Z

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24033810

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phosphorylation

Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

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P2860

P2860

Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors.

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P1476

P2093

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