Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development.
about
Identification of SOX3 as an XX male sex reversal gene in mice and humansBuilding the mammalian testis: origins, differentiation, and assembly of the component cell populationsThree-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovaryMammalian sex determination—insights from humans and mice.Genetic control of testis developmentFGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glandsNR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex developmentFOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice.In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures.Regulation of sex determination in mice by a non-coding genomic region.Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determinationHuman gene correlation analysis (HGCA): a tool for the identification of transcriptionally co-expressed genes.Transient development of ovotestes in XX Sox9 transgenic mice.Regulation of male sex determination: genital ridge formation and Sry activation in mice.Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literatureSox9 is critical for suppression of neurogenesis but not initiation of gliogenesis in the cerebellumCellular microenvironment dictates androgen production by murine fetal Leydig cells in primary cultureDSDs: genetics, underlying pathologies and psychosexual differentiation.Identification of novel markers of mouse fetal ovary development.Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.Turnover of Sex Chromosomes in Celebensis Group Medaka Fishes.The molecular and cellular basis of gonadal sex reversal in mice and humans.Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration.Molecular mechanism of male differentiation is conserved in the SRY-absent mammal, Tokudaia osimensis.Diagnostic Application of Targeted Next-Generation Sequencing of 80 Genes Associated with Disorders of Sexual Development.Sex determination and the control of Sox9 expression in mammals.SRY protein function in sex determination: thinking outside the box.The SOX family of genes in cancer development: biological relevance and opportunities for therapy.Gene mutations associated with anomalies of human gonad formation.Genetic regulation of mammalian gonad development.Vertebrate sex determination: evolutionary plasticity of a fundamental switch.Migration pathways of sacral neural crest during development of lower urogenital tract innervation.The Battle of the Sexes: Human Sex Development and Its Disorders.Anomalies in human sex determination provide unique insights into the complex genetic interactions of early gonad development.Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development.Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice.46,XX male - testicular disorder of sexual differentiation (DSD): hormonal, molecular and cytogenetic studies.Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis.
P2860
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P2860
Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Sox10 gain-of-function causes ...... disorders of sex development.
@en
Sox10 gain-of-function causes ...... disorders of sex development.
@nl
type
label
Sox10 gain-of-function causes ...... disorders of sex development.
@en
Sox10 gain-of-function causes ...... disorders of sex development.
@nl
prefLabel
Sox10 gain-of-function causes ...... disorders of sex development.
@en
Sox10 gain-of-function causes ...... disorders of sex development.
@nl
P2860
P50
P356
P1476
Sox10 gain-of-function causes ...... disorders of sex development.
@en
P2093
Deon Knight
Tara-Lynne Davidson
P2860
P304
P356
10.1093/HMG/DDP520
P577
2009-11-20T00:00:00Z