Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.
about
Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activityInvestigation of the Josephin Domain protein-protein interaction by molecular dynamicsStructural biology by NMR: structure, dynamics, and interactions.Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates.Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.Functional interactions as a survival strategy against abnormal aggregationCharacterization of the conformational fluctuations in the Josephin domain of ataxin-3.Location trumps length: polyglutamine-mediated changes in folding and aggregation of a host proteinAllosteric regulation of deubiquitylase activity through ubiquitination.Toward understanding Machado-Joseph diseaseInfrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.Polyubiquitin binding and disassembly by deubiquitinating enzymes.Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamicsSmall-angle X-ray and neutron scattering as a tool for structural systems biology.The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.Deciphering conformational transitions of proteins by small angle X-ray scattering and normal mode analysis.A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics.SAS-Based Structural Modelling and Model Validation.Bayesian estimation of NMR restraint potential and weight: a validation on a representative set of protein structures.Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?
P2860
Q24310046-BC920470-8512-4C6B-A1E9-549659CCC1CBQ27343004-5278CC02-A777-4295-9FA3-0C4967279AE6Q30372281-8CF42218-8029-48EB-A927-E8037EB8B561Q31035962-26345CFE-F41A-4DD1-89C9-916B29EC4F9CQ33935094-38165C72-8525-4AAC-B3CE-FB0FB5FE420EQ34421847-F25C3DCB-F976-4E2D-A66B-DF8DFF96B9F8Q34727544-6D4FA878-EE72-4A65-AE59-FAE936D3F3A5Q35051262-7A8B520F-8EBD-4A26-9728-A366690B7B51Q35596666-FE5D8647-B277-4D46-941B-F690BC8C1CA4Q35837355-0F253801-EB42-4380-A210-EB7ABF7BE2CDQ35917010-F7F03D2D-02C5-4252-959D-0165DEA3B7B5Q37401250-3D3851EB-8BDD-4453-B6FE-5BFBB01248BCQ37593610-5DD33719-49BA-45FC-9788-37C7DA003313Q37756154-3C66E4CB-470A-4EB9-AA68-1DF6D3487CEFQ39965496-C5CD02B3-44BC-4B38-82F1-57CE2561D69EQ40270412-413E232D-E6D8-46AE-9FB9-F7A7BD0D61B3Q41113362-D6D63999-B73C-4F7C-96C0-B3E270502551Q41359094-46FC285D-BF1D-4902-9451-3ECE7F60814AQ47316596-CB15B75E-D48F-4484-9574-A7A6D610C820Q47388542-235AF5E3-CC4C-48BE-82BF-92D8C6C8AADAQ50575490-97E5BA61-DFF5-450D-9B74-509DE612FC76Q58766259-86DAFBAB-D4D7-4EFE-BEE1-96C78DE09D02
P2860
Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Structure validation of the Jo ...... ence for an open conformation.
@en
Structure validation of the Jo ...... ence for an open conformation.
@nl
type
label
Structure validation of the Jo ...... ence for an open conformation.
@en
Structure validation of the Jo ...... ence for an open conformation.
@nl
prefLabel
Structure validation of the Jo ...... ence for an open conformation.
@en
Structure validation of the Jo ...... ence for an open conformation.
@nl
P50
P1476
Structure validation of the Jo ...... ence for an open conformation.
@en
P2093
Giuseppe Nicastro
Laura Masino
P2888
P304
P356
10.1007/S10858-006-9092-Z
P577
2006-11-10T00:00:00Z