Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.
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Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseasesLymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugsPromising treatments of tomorrow for multiple sclerosis.T-lymphocyte Kv1.3 channel activation triggers the NLRP3 inflammasome signaling pathway in hypertensive patientsActivated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers.Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.T cells in vascular inflammatory diseasesBlockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent.High glucose induces CCL20 in proximal tubular cells via activation of the KCa3.1 channelFunctional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling.Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.Inhibitory effects of telmisartan on culture and proliferation of and Kv1.3 potassium channel expression in peripheral blood CD4+ T lymphocytes from Xinjiang Kazakh patients with hypertension.Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis modelT Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 BlockersBlockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic miceKv1.3 potassium channels as a therapeutic target in multiple sclerosis.KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis.The functional network of ion channels in T lymphocytesPhysiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease.Novel therapies for memory cells in autoimmune diseases.Roles of lymphocyte kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels.Usefulness of targeting lymphocyte Kv1.3-channels in the treatment of respiratory diseases.The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies.Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.Upregulation of K2P5.1 potassium channels in multiple sclerosis.Safety and pharmacodynamics of dalazatide, a Kv1.3 channel inhibitor, in the treatment of plaque psoriasis: A randomized phase 1b trialBlockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection.Voltage-dependent biphasic effects of chloroquine on delayed rectifier K(+)-channel currents in murine thymocytes.Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.Overexpression of Delayed Rectifier K(+) Channels Promotes In situ Proliferation of Leukocytes in Rat Kidneys with Advanced Chronic Renal Failure.Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region.Potassium channels, renal fibrosis, and diabetes.[4-Aminopyridine (Fampridine). A new attempt for the symptomatic treatment of multiple sclerosis].Novel alpha-KTx sites in the BK channel and comparative sequence analysis reveal distinguishing features of the BK and KV channel outer pore.Enantioselective total synthesis of (-)-candelalides A, B and C: potential Kv1.3 blocking immunosuppressive agents.Analysis by flow cytometry of calcium influx kinetics in peripheral lymphocytes of patients with rheumatoid arthritis.
P2860
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P2860
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@en
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@nl
type
label
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@en
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@nl
prefLabel
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@en
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@nl
P2093
P1476
Characterization of the functi ...... 3 in human CD4+ T lymphocytes.
@en
P2093
Katharine A Whartenby
Michael Pennington
Qiong Jiang
P304
P356
10.4049/JIMMUNOL.179.7.4563
P407
P577
2007-10-01T00:00:00Z