about
In search of novel ligands using a structure-based approach: a case study on the adenosine A2A receptorProteochemometric modeling in a Bayesian framework.A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunitsScanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein coupling.Domains for activation and inactivation in G protein-coupled receptors--a mutational analysis of constitutive activity of the adenosine A2B receptor.Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2.Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido[2,1-f]purine-2,4-dione Derivatives as Human Adenosine A3 Receptor AntagonistsA covalent antagonist for the human adenosine A2A receptor.Beyond the hype: deep neural networks outperform established methods using a ChEMBL bioactivity benchmark set.Removal of human ether-à-go-go related gene (hERG) K+ channel affinity through rigidity: a case of clofilium analogues.Structure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists.Interacting with GPCRs: Using Interaction Fingerprints for Virtual ScreeningRelative Binding Free Energy Calculations Applied to Protein Homology Models.Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A1 receptor antagonists.Selecting an optimal number of binding site waters to improve virtual screening enrichments against the adenosine A2A receptor.
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description
Dutch researcher
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Bart Lenselink
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P106
P1960
HCo5_kIAAAAJ
P21
P31
P496
0000-0001-5459-2978