Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.
about
Osteocyte control of bone formation via sclerostin, a novel BMP antagonistTransgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotypeDecrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritisThe Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular ChondrocytesOveractive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophySclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteinsIncudomalleal joint formation: the roles of apoptosis, migration and downregulation.SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.Global comparative transcriptome analysis of cartilage formation in vivo.The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturationFGFR3 induces degradation of BMP type I receptor to regulate skeletal development.BMP signaling stimulates cellular differentiation at multiple steps during cartilage development.Expression and functional study of extracellular BMP antagonists during the morphogenesis of the digits and their associated connective tissues.Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.Smad6 is essential to limit BMP signaling during cartilage developmentSmad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopeniaBiomaterial-mediated strategies targeting vascularization for bone repair.Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton.Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations.Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts.Osteogenic potential of BMP-2-releasing self-assembled membranes.Animal models of typical heterotopic ossification.New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanismArticular cartilage tissue engineering: the role of signaling molecules.Generation of scaffoldless hyaline cartilaginous tissue from human iPSCs.Comparison of GDF5 and GDNF as neuroprotective factors for postnatal dopamine neurons in ventral mesencephalic cultures.Signaling networks in joint development.MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytes.TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.Sox9-dependent transcriptional regulation of the proprotein convertase furin.CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling.Dedifferentiation of human articular chondrocytes is associated with alterations in expression patterns of GDF-5 and its receptors.Ligand- and stage-dependent divergent functions of BMP signaling in the differentiation of embryonic skeletogenic progenitors in vitro.TGF-β signalling and PEG10 are mutually exclusive and inhibitory in chondrosarcoma cellsThyroid hormone-induced hypertrophy in mesenchymal stem cell chondrogenesis is mediated by bone morphogenetic protein-4.c-Jun is required for the specification of joint cell fates.Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage.
P2860
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P2860
Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@en
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@nl
type
label
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@en
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@nl
prefLabel
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@en
Bone morphogenetic protein sig ...... lopment during skeletogenesis.
@nl
P2093
P1476
Bone morphogenetic protein sig ...... elopment during skeletogenesis
@en
P2093
Hideki Yoshikawa
Takahiro Miyaji
Takahiro Ochi
Takanobu Nakase
Tomoatsu Kimura
P2860
P304
P356
10.1359/JBMR.2002.17.5.898
P577
2002-05-01T00:00:00Z