Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons.
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Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complexA consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interaction.Targeting von Willebrand factor and platelet glycoprotein Ib receptor.The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey modelVon Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study.von Willebrand factor: an emerging target in stroke therapy.Epitope mapping of human VWF A3 recognized by monoclonal antibody SZ-123 and SZ-125 using MALDI mass spectrometry.Platelet adhesion under flow.Von Willebrand factor, platelets and endothelial cell interactions.Rapidly regulating platelet activity in vivo with an antidote controlled platelet inhibitorNewer agents in antiplatelet therapy: a review.Antithrombotic effect of Z4A5 on coronary thrombosis in a canine model of acute unstable angina.Platelet receptors and signaling in the dynamics of thrombus formation.Platelet receptor signaling in thrombus formation.Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke.On the versatility of von Willebrand factorA duplex issue: (i) time to re-appraise the diagnosis and classification of von Willebrand disorder, and (ii) clarification of the roles of von Willebrand factor collagen binding and ristocetin cofactor activity assays.Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain.The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen.alphaIIbbeta3 antagonism vs. antiadhesive treatment to prevent platelet interactions with vascular subendothelium.New insights into the non-hemostatic role of von Willebrand factor in endothelial protection.The von Willebrand factor self-association is modulated by a multiple domain interactionNovel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction
P2860
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P2860
Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Inhibition of the von Willebra ...... thrombus formation in baboons.
@en
Inhibition of the von Willebrand
@nl
type
label
Inhibition of the von Willebra ...... thrombus formation in baboons.
@en
Inhibition of the von Willebrand
@nl
prefLabel
Inhibition of the von Willebra ...... thrombus formation in baboons.
@en
Inhibition of the von Willebrand
@nl
P2093
P1433
P1476
Inhibition of the von Willebra ...... thrombus formation in baboons.
@en
P2093
Dongmei Wu
Harry F Kotze
Hilde Depraetere
Muriel Meiring
Nancy Cauwenberghs
P304
P356
10.1182/BLOOD.V99.10.3623
P407
P577
2002-05-01T00:00:00Z