Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis.
about
Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cellsOligodendrocytes: biology and pathologyDifferent proteolipid protein mutants exhibit unique metabolic defects.Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brainAxon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease.Molecular pathogenesis of neuroinflammation.The myelin mutants as models to study myelin repair in the leukodystrophies.Gait abnormalities and progressive myelin degeneration in a new murine model of Pelizaeus-Merzbacher disease with tandem genomic duplication.DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsyProgesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis.Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cordProteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.Trafficking of PLP/DM20 and cAMP signaling in immortalized jimpy oligodendrocytes.Thymic stromal lymphopoietin is expressed in the intact central nervous system and upregulated in the myelin-degenerative central nervous system.The "window of susceptibility" for inflammation in the immature central nervous system is characterized by a leaky blood-brain barrier and the local expression of inflammatory chemokines.NG2 plays a role in neuroinflammation but is not expressed by immune cells.Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease.Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease
P2860
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P2860
Transgenic Lewis rats overexpressing the proteolipid protein gene: myelin degeneration and its effect on T cell-mediated experimental autoimmune encephalomyelitis.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@en
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@nl
type
label
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@en
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@nl
prefLabel
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@en
Transgenic Lewis rats overexpr ...... autoimmune encephalomyelitis.
@nl
P2093
P50
P356
P1476
Transgenic Lewis rats overexpr ...... l autoimmune encephalomyelitis
@en
P2093
P2888
P304
P356
10.1007/S004010051035
P577
1999-06-01T00:00:00Z