Estimation of agonist affinity and efficacy by direct, operational model-fitting.
about
The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulationBeyond eyeballing: fitting models to experimental data.Functional methods for quantifying agonists and antagonists.5-HT7 receptor efficacy distribution throughout the canine stomachClassification of platelet and vascular prostaglandin D2 (DP) receptors: estimation of affinities and relative efficacies for a series of novel bicyclic ligands. With an appendix on goodness-of-fit analyses.Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2Interactions between responses mediated by activation of adenosine A2 receptors and alpha 1-adrenoceptors in the rabbit isolated aortaHydromorphone efficacy and treatment protocol impact on tolerance and mu-opioid receptor regulation.Modelling of alpha1-adrenoceptor-mediated temporal dynamics of inotropic response in rat heart to assess ligand binding and signal transduction parameters.Quantitative assessment of minimal effective concentration of erythropoiesis-stimulating agents.Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity.An estimation of beta 2-adrenoceptor reserve on human bronchial smooth muscle for some sympathomimetic bronchodilators.The long-acting β2 -adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent mannerAnalysis of the agonist activity of fenoldopam (SKF 82526) at the vascular 5-HT2 receptor.Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.Pharmacological estimation of agonist affinity: detection of errors that may be caused by the operation of receptor isomerisation or ternary complex mechanisms.Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries.An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics.Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding.Endothelial modulation of alpha 1-adrenoceptor contractile responses in the tail artery of spontaneously hypertensive rats.Modelling the changes induced by chronic desipramine treatment on the factors governing the agonism at prejunctional alpha 2-adrenoceptorsAnalysis of the activity of alpha 1-adrenoceptor antagonists in rat aorta.Analysis of the effects of alpha 1-adrenoceptor antagonists on noradrenaline-mediated contraction of rat small mesenteric arteryEstimation of the efficacy and affinity of the beta 2-adrenoceptor agonist salmeterol in guinea-pig trachea.Quantitative analysis of the agonist and antagonist actions of some ATP analogues at P2X-purinoceptors in the rabbit ear arteryEstimation of partial agonist affinity by interaction with a full agonist: a direct operational model-fitting approach.Characterization of 5-HT7-receptor-mediated gastric relaxation in conscious dogs.A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses.Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding.
P2860
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P2860
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@en
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@nl
type
label
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@en
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@nl
prefLabel
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@en
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@nl
P2093
P1476
Estimation of agonist affinity and efficacy by direct, operational model-fitting.
@en
P2093
P304
P356
10.1016/0160-5402(90)90066-T
P577
1990-05-01T00:00:00Z